Abstract 1739P
Background
Coronavirus disease 2019 (COVID-19) pandemic is affecting a high percentage of the population at an unprecedented rate. Cancer patients comprise a subgroup especially vulnerable to this infection. However, to date, there is a critical need of medical data to optimize the management of these patients.
Methods
We present a prospective analysis of epidemiological, clinical, radiological and laboratory data of consecutive adult cancer patients seen in the Medical Oncology Department of the Hospital Universitario Clínico San Carlos (Madrid, Spain), and admitted to hospital and tested for COVID-19 between February 21 and April 9, 2020 due to clinical suspicion of infection.
Results
193 patients with suspected COVID-19 were prospectively followed. Data from 58 patients with confirmed COVID-19 and active cancer or diagnosed within the last 5 years were analyzed. The most frequent malignancy was lung cancer (22%). 45 patients (78%) were on active cancer treatment, of which 36 (84%) had their last dose administered within 14 days before admission. Most common findings on presentation included fever (59%), cough (53%), and dyspnea (48%), and 25 (43%) patients showed oxygen saturation levels below 95%. Radiologically, 41 (71%) patients presented an abnormal pattern, the most frequent being infiltrates (62%). 17 (29.3%) patients died in hospital and 41 (61.7%) were discharged with clinical resolution of the event. Multivariable logistic regression showed higher odds of in-hospital death associated with a history of cardiovascular disease (odds ratio 5.14, 1.28-22.55; p=0.023), lower oxygen saturation levels (1.12, 1.01-1.30; p=0.049), and neutropenia (9.01, 1.08-100; p=0.047) on admission.
Conclusions
The data presented here captures the course of COVID-19 in cancer patients during the initial phase of the outbreak and may help identify patients with a higher risk of death from COVID-19 at the time of diagnosis so that earlier and more intensive measures can be articulated.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Hospital Clínico San Carlos.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.