Abstract 244P
Background
Breast cancer (BC) is the most common cause of cancer-related deaths in women under 45 years. It has been reported as a more aggressive disease, with a more aggressive treatment and a worse survival with more serious psychosocial consequences. Evidence about epidemiology, biologic behaviours, and treatment strategies are needed to help clinicians understand this disease.
Methods
We conducted a retrospective study selecting patients ≤45 years with BC diagnosis in the Breast Cancer Unit of the Puerta de Hierro Hospital between 2014 and 2019. Epidemiological, clinical and pathological information was collected. We aim to understand the characteristics of BCYW population, and assess quality of care of the diagnostic and treatments.
Results
348 patients with diagnostic of BC were selected. Median age was 41 years (38-44). Table: 244P
| ≤35 years (%) | 36-40 years (%) | ≥41 years | All | |
| n (%) | 33 (9%) | 103 (30%) | 212 (61%) | 348 |
| Pregnancy | 57,6 | 75,8 | 85,2 | 79,9 |
| Breast feeding | 37,5 | 43,4 | 52,9 | 49 |
| Never smoker | 68,8 | 55 | 48,1 | 52 |
| Oral contraceptives | 54,6 | 35,9 | 46,2 | 44,3 |
| Body mass index | 21,5 | 22,7 | 23,6 | 22,8 |
| FA breast cancer | 36,4 | 28,2 | 32,6 | 32 |
| FA ovary cancer | 12,1 | 3, | 3,8 | 4,6 |
| BRCA1/2 + | 12,1 | 8,7 | 6,1 | 7,4 |
| Histology | ||||
| Ductal | 93,9 | 86,4 | 82,1 | 84,5 |
| Lobular | 3,1 | 3,9 | 10,9 | 8,3 |
| Other | 3 | 9,7 | 7 | 7,2 |
| Stage | ||||
| I | 33,3 | 36,4 | 40,1 | 38,1 |
| II | 46,7 | 37,5 | 37,4 | 38,4 |
| III | 16,7 | 22,7 | 16,6 | 18,6 |
| IV | 3,3 | 3,4 | 5,9 | 4,9 |
| Axillary staging + | 43,3 | 46,2 | 42,5 | 43,8 |
| Subtypes | ||||
| TN | 12,9 | 7,2 | 13,1 | 11,2 |
| RRHH+ HER2- | 61,3 | 75,3 | 68,1 | 69,5 |
| RRHH+ HER2+ | 22,6 | 11,3 | 14,6 | 14,3 |
| RRHH- HER2+ | 3,2 | 6,2 | 4,2 | 5 |
Conclusions
In our BCYW cohort, no association was found between age groups and clinical or pathological characteristics, which differs from other previously published studies reporting the worst prognosis in young women. Our cohort distribution, according to stages and subtypes, is similar to the global population described in the literature. This suggests the need for a detailed BCYW analysis to find keys for an specific management of this population and prevent age-related disparities in BC care.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.