Abstract 1830P
Background
The low muscular component is associated with diminished cancer treatment outcomes and increased toxicities. Various studies focused on advanced measurement techniques using dual energy X-ray absorptiometry (DEXA) scan or CT-based analysis, while study on bioelectrical impedance analysis (BIA) was limited. This study examined the association of body composition measured by BIA on the hematologic adverse events in early-stage breast cancer (EBC) patients receiving chemotherapy.
Methods
A total of 144 female patients with EBC were enrolled in this study. Body weight (BW) and fat-free mass (FFM) were measured by BIA analyzer before starting of the first cycle of chemotherapy. BW and FFM were converted into body mass index (BMI) and fat-free mass index (FFMI) by dividing with squared height (in meter) of the patient. The association between FFMI and composite adverse events (CAE), including grade 4 neutropenia, febrile neutropenia and relative dose intensity < 85% were explored.
Results
Of the 144 patients, CAE occurred in 85 patients (59%), and point biserial correlation showed an inverse correlation between FFMI and CAE. Per the international consensus, none of these patients matched with sarcopenic criteria (FFMI < 11.4 kg/m2). AUC analysis revealed that FFMI of < 14.85 kg/m2 should be the cut point for low FFMI. Using this cut point, 85 patients were classified as low FFMI, and 62 patients (72.9%) had CAE with a notable relative risk (RR) of 1.86 (p < 0.001). After adjusting for other factors, low FFMI was significantly associated with a high CAE rate (adjusted odds ratio (OR) 4.562, p < 0.001).
Conclusions
A low FFMI was significantly correlated with increased risk of severe neutropenia and decreased relative dose intensity in patients with EBC receiving chemotherapy. FFMI measured by BIA is a useful tool to detect patient-at-risk in this situation, so preventive measures could be considered to improve treatment outcomes.
Clinical trial identification
TCTR20190702004.
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.