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Proffered Paper - SARS-CoV-2 and cancer 2

LBA72 - Assessment of clinical and laboratory prognostic factors in patients with cancer and SARS-CoV-2 infection: The COVID-19 and Cancer Consortium (CCC19)

Date

20 Sep 2020

Session

Proffered Paper - SARS-CoV-2 and cancer 2

Presenters

Petros Grivas

Citation

Annals of Oncology (2020) 31 (suppl_4): S1142-S1215. 10.1016/annonc/annonc325

Authors

P. Grivas1, J. Warner2, Y. Shyr3, D. Shah4, S.M. Rubinstein5, N.M. Kuderer6, T.K. Choueiri7, D. Rivera8, C. Painter9, M.A. Thompson10, S. Peters11, A. Desai12, A.R. Khaki13, N.A. Pennell14, J. Hawley15, B. Halmos16, M.M. Puc17, G.H. Lyman18, B.I. Rini19, G. Lopes20

Author affiliations

  • 1 Medicine, Division Of Oncology, University of Washington, Fred Hutchinson CRC, Seattle Cancer Care Alliance, 98109-4405 - Seattle/US
  • 2 Medicine, Institution/Organization Vanderbilt University Medical Center, 37203 - Nashville/US
  • 3 Biostatistics, Institution/Organization Vanderbilt University Medical Center, 37203 - Nashville/US
  • 4 Population Health Sciences, Mays Cancer Center at UT Health San Antonio MD Anderson, 78229 - San Antonio/US
  • 5 Medicine, Division Of Hematology, Vanderbilt University Medical Center, Nashville/US
  • 6 Medical Oncology, Advanced Cancer Research Group, Seattle/US
  • 7 Medical Oncology Dept., Dana Farber Cancer Institute, 2215 - Boston/US
  • 8 Division Of Cancer Control And Population Sciences, National Cancer Institute, 20850 - Rockville/US
  • 9 Cancer Program, Broad Institute, Cambridge/US
  • 10 Aurora Cancer Care, Advocate Aurora Health, 53215 - Milwaukee/US
  • 11 Multidisciplinary Oncology Center, Centre Hospitalier Universitaire Vaudois - CHUV, 1011 - Lausanne/CH
  • 12 Medicine, University of Connecticut, 06106 - Farmington/US
  • 13 Medicine, University of Washington, 98195 - Seattle/US
  • 14 Hematology And Medical Oncology, Cleveland Clinic, Cleveland/US
  • 15 Medicine, Columbia University Irving Medical Center, 10032 - New York City/US
  • 16 Department Of Oncology, Montefiore/Albert Einstein Cancer Center, 10461 - Bronx/US
  • 17 Surgery, Virtua Health, 08053 - Marlton/US
  • 18 Public Health Sciences, Fred Hutchinson Cancer Research Center, 98109 - Seattle/US
  • 19 Division Of Hematology/oncology, Vanderbilt University Medical Center, 37232 - Nashville/US
  • 20 Sylvester Comprehensive Cancer Center, University of miami, 33146 - Miami/US
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Resources

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Abstract LBA72

Background

The impact of clinicopathologic factors, cancer type, stage or therapies on outcomes of pts with COVID19 is not well defined. We systematically and comprehensively identified and assessed factors associated with high mortality (M) in the largest cohort of pts with cancer and COVID-19.

Methods

CCC19 cohort includes pts with active or prior cancer and COVID-19 across US/international sites and collaborates with ESMO-CoCARE. Analysis was limited to lab-confirmed COVID-19. Primary endpoint: all-cause 30-day M. Multivariable logistic regression was used to assess association between 30-day M and a priori identified demographic/clinicopathologic risk factors (age, sex, race, region, smoking, obesity, comorbidities, ECOG PS, cancer status, recent [in 3 months] cancer treatment, cancer type, baseline COVID19 severity). Exploratory analysis used separate models adjusted for demographic/clinicopathologic factors to assess associations of lab parameters with 30-day M.

Results

As of 31 July 2020, 4169 pts have been accrued; median follow-up 30 days (IQR 21-70), median age 66 (IQR 56-76), 50% men, 92% from US, breast and prostate cancer were most common; 38% had active cancer, 56% required hospitalization and 16% ICU. In 3830 pts with lab confirmed COVID19, 30-day M was 14% overall and 23% in hospitalized pts. Table shows adjusted [a]OR for overall and hospitalized pts. Age, male sex, smoking, >2 comorbidities, ECOG PS≥1, progressive cancer, hematologic or >1 cancer, and severe baseline COVID19 at presentation were associated with worse 30-day M. In hospitalized pts, high or low ALC, high ANC, low platelets, abnormal creatinine, d-dimer, HS-troponin and CRP were also associated with worse 30-day M. Table: LBA72

OVERall (N=3819) Hospitalized (N=2168)
Age 1.6 (1.4-1.6) 1.6 (1.4-1.6)
Male 1.3 (1.0-1.6) 1.3 (1.0-1.6)
Ever Smoker 1.3 (1.0-1.6) 0.8 (0.6-1.0)
>2 Comorbidities 2.0 (1.1-3.6) 1.9 (1.0-3.5)
ECOG PS 1 1.8 (1.3-2.6) 0.6 (0.4-0.8)
ECOG PS >1 3.5 (2.5-5.0) 1.8 (1.3-2.4)
progressIVE CA 2.6 (1.8-3.7) 2.4 (1.7-3.5)
Recent Therapy 1.4 (1.0-1.8) 1.4 (1.0-1.8)
HemE CA 1.4 (1.0-1.8) 1.2 (0.9-1.6)
>1 ca 1.4 (1.0-1.9) 1.2 (0.9-1.7)
Mod C19 5.5 (3.9-7.7) 0.7 (0.4-1.0)
Sev C19 23.4 (16.1-34.1) 4.1 (3.1-5.3)
LABs
ALC>ULN 2.1 (1.0-4.2)
ALC 1.4 (1.1-1.9)
ANC>ULN 1.9 (1.4-2.5)
PLT 1.4 (1.1-1.8)
AB CREATInine 1.5 (1.2-2.0)
AB D-DIMER 2.0 (1.2-3.5)
AB HS-TROP 2.1 (1.3-3.5)
AB CRP 2.1 (1.1-4.2)

*AB=abnormal.

Conclusions

We confirmed a priori identified risk factors for poor prognosis in the largest COVID-19/cancer cohort and performed initial analysis of lab parameters, informing risk assessment.

Clinical trial identification

NCT04354701.

Editorial acknowledgement

Legal entity responsible for the study

The COVID-19 and Cancer Consortium (CCC19).

Funding

Has not received any funding.

Disclosure

P. Grivas: Honoraria (self), Research grant/Funding (institution): AstraZeneca; Honoraria (self), Research grant/Funding (institution): Bayer; Honoraria (self), Speaker Bureau/Expert testimony: Bristol-Myers Squibb; Honoraria (self), Research grant/Funding (institution): Clovis Oncology; Honoraria (self): Driver; Honoraria (institution): EMD Serono; Honoraria (self): Exelixis; Honoraria (self): Foundation Medicine; Honoraria (self), Research grant/Funding (institution): Genentech; Honoraria (self): Genzyme; Honoraria (self): GlaxoSmithKline; Honoraria (self): Heron Therapeutics; Honoraria (self): Janssen; Honoraria (self), Research grant/Funding (institution): Merck; Honoraria (self), Research grant/Funding (institution): Mirati Therapeutics; Honoraria (self), Research grant/Funding (institution): Pfizer; Honoraria (self): Roche; Honoraria (self): Seattle Genetics; Honoraria (self), Research grant/Funding (institution): QED Therapeutics; Research grant/Funding (institution): KureIT; Research grant/Funding (institution): Bavarian Nordic; Research grant/Funding (institution): Debiopharm; Research grant/Funding (institution): Immunomedics; Research grant/Funding (institution): Oncogenex. J. Warner: Advisory/Consultancy: IBM Watson Health; Advisory/Consultancy: Westat; Leadership role, Shareholder/Stockholder/Stock options: HemOnc.org LLC; Travel/Accommodation/Expenses: American Society of Clinical Oncology; Research grant/Funding (institution): National Cancer Institute. Y. Shyr: Advisory/Consultancy: Roche; Advisory/Consultancy: Novartis; Advisory/Consultancy: Pfizer; Advisory/Consultancy: Johnson & Johnson; Advisory/Consultancy: GlaxoSmithKline; Advisory/Consultancy, Speaker Bureau/Expert testimony: AstraZeneca; Speaker Bureau/Expert testimony: Boehringer Ingelheim; Speaker Bureau/Expert testimony: Eisai. D. Shah: Research grant/Funding (institution), American Cancer Society and the Hope Foundation for Cancer Research (Mentored Research Scholar Grants in Applied and Clinical Research, MRSG-16-152-01-CCE; PI: Shah DP), and grants from the National Cancer Institute (P30 CA054174; PI: Mesa R): American Cancer Society; Research grant/Funding (institution): National Cancer Institute; Research grant/Funding (institution): Hope Foundation for Cancer Research. N.M. Kuderer: Advisory/Consultancy, Travel/Accommodation/Expenses: BMS; Advisory/Consultancy, Travel/Accommodation/Expenses: Janssen; Advisory/Consultancy: Celldex; Advisory/Consultancy: Invitae; Advisory/Consultancy: Total Health; Advisory/Consultancy: Beyond Springs; Advisory/Consultancy: Bayer; Advisory/Consultancy: Spectrum Pharmaceuticals. T.K. Choueiri: Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): AstraZeneca; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Alexion; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Bayer; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Bristol-Myers Squibb/ER Squibb and sons; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Cerulean; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Eisai; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Foundation Medicine; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Exelixis; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Ipsen; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Tracon; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Genentech; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): F Hoffmann-La Roche/Roche/Roche Products; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): GlaxoSmithKline; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Eli Lilly; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Merck; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Novartis; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Peloton; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Pfizer; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Prometheus Labs; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Corvus; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Calithera; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Analysis Group; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Sanofi/Aventis; Honoraria (self), Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): Takeda; Honoraria (self): EMD Serono; Honoraria (self): Up-to-Date; Honoraria (self): NCCN Analysis Group; Honoraria (self), A healthcare communications company with several brands such as OncLive, PeerView and PER: Michael J Hennessy Associates; Honoraria (self): Research to Practice; Honoraria (self), and Kidney Cancer Journal, Clinical Care Options, Platform Q, Navinata Healthcare, Harborside Press, American Society of Clinical Oncology, New England Journal of Medicine, The Lancet Oncology, Heron Therapeutics: L-path. C. Painter: Shareholder/Stockholder/Stock options: Pfizer; Shareholder/Stockholder/Stock options: Epizyme; Shareholder/Stockholder/Stock options: Inovio; Shareholder/Stockholder/Stock options: OPKO Health Inc.; Shareholder/Stockholder/Stock options: Roche. M.A. Thompson: Honoraria (institution): AbbVie; Honoraria (institution): BMS; Honoraria (institution): CRAB CTC; Honoraria (institution): Denovo; Honoraria (institution): Hoosier Research Network; Honoraria (institution): Lilly; Honoraria (institution): LynxBio; Honoraria (institution): Strata Oncology; Honoraria (institution), Advisory/Consultancy: Takeda; Honoraria (institution): TG Therapeutics; Advisory/Consultancy: Adaptive; Advisory/Consultancy: AIM Specialty Health; Advisory/Consultancy: Celgene (BMS); Advisory/Consultancy: GSK; Advisory/Consultancy: VIA Oncology (now Elsevier Clinical Path); Travel/Accommodation/Expenses, Shareholder/Stockholder/Stock options: Doximity; Travel/Accommodation/Expenses: Syapse; Licensing/Royalties: UpToDate; Non-remunerated activity/ies: Strata Oncology Advisory Board. S. Peters: Honoraria (institution), Advisory/Consultancy: AbbVie; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution): Amgen; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: AstraZeneca; Honoraria (institution), Advisory/Consultancy: Bayer; Honoraria (institution), Advisory/Consultancy: Biocartis; Honoraria (institution), Advisory/Consultancy: Bioinvent; Honoraria (institution), Advisory/Consultancy: Blueprint Medicines; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution): Boehringer-Ingelheim; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: Bristol-Myers Squibb; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution): Clovis; Honoraria (institution), Advisory/Consultancy, Travel/Accommodation/Expenses: Daiichi Sankyo; Honoraria (institution), Advisory/Consultancy: Debiopharm; Honoraria (institution), Advisory/Consultancy: Eli Lilly; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution): F. Hoffmann-La Roche; Honoraria (institution), Advisory/Consultancy: Foundation Medicine; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: Illumina; Honoraria (institution), Advisory/Consultancy: Janssen; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: Merck Sharp and Dohme; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution): Merck Serono; Honoraria (institution), Advisory/Consultancy: Merrimack; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution): Novartis; Honoraria (institution), Advisory/Consultancy: PharmaMar; Honoraria (institution), Advisory/Consultancy, Research grant/Funding (institution): Pfizer; Honoraria (institution), Advisory/Consultancy: Regeneron; Honoraria (institution), Advisory/Consultancy: Sanofi; Honoraria (institution), Advisory/Consultancy, Travel/Accommodation/Expenses: Seattle Genetics; Honoraria (institution), Advisory/Consultancy: Takeda; Honoraria (institution), Advisory/Consultancy: Vaccibody; Travel/Accommodation/Expenses: Roche; Research grant/Funding (institution): Biodesix. A.R. Khaki: Shareholder/Stockholder/Stock options: Pfizer; Shareholder/Stockholder/Stock options: Merck. N.A. Pennell: Advisory/Consultancy: Astrazeneca; Advisory/Consultancy: Merck; Advisory/Consultancy: Eli Lilly; Advisory/Consultancy: Genentech; Advisory/Consultancy: BMS; Advisory/Consultancy: Amgen. B. Halmos: Advisory/Consultancy, Research grant/Funding (institution): AstraZeneca; Advisory/Consultancy, Research grant/Funding (institution): Bristol Myers Squibb; Advisory/Consultancy, Research grant/Funding (institution): Merck; Advisory/Consultancy, Research grant/Funding (institution): Boehringer-Ingelheim; Advisory/Consultancy, Research grant/Funding (institution): Novartis; Advisory/Consultancy: Pfizer; Advisory/Consultancy, Research grant/Funding (institution): Amgen; Advisory/Consultancy: Spectrum; Advisory/Consultancy: Takeda; Advisory/Consultancy, Research grant/Funding (institution): Guardant Health; Advisory/Consultancy: Foundation One; Advisory/Consultancy, Research grant/Funding (institution): Genentech; Research grant/Funding (institution): AbbVie; Research grant/Funding (institution): Advaxis; Research grant/Funding (institution): GSK; Research grant/Funding (institution): Eli-Lilly; Research grant/Funding (institution): Mirati. G.H. Lyman: Advisory/Consultancy: G1 Therapeutics; Advisory/Consultancy: Spectrum; Advisory/Consultancy: Invitae; Advisory/Consultancy: Sandoz; Advisory/Consultancy: Samsung; Advisory/Consultancy: Beyond Spring; Advisory/Consultancy, Travel/Accommodation/Expenses: Bayer; Advisory/Consultancy: Mylan; Research grant/Funding (institution): Amgen. B.I. Rini: Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: Merck; Advisory/Consultancy, Research grant/Funding (institution): Roche; Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: Pfizer; Advisory/Consultancy, Research grant/Funding (institution): AVEO; Advisory/Consultancy: Arravive; Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: BMS; Advisory/Consultancy: 3D Medicines; Advisory/Consultancy: Synthorx; Advisory/Consultancy: Surface Oncology; Shareholder/Stockholder/Stock options: PTC Therapeutics; Research grant/Funding (institution): AstraZeneca. G. Lopes: Honoraria (self), Travel/Accommodation/Expenses: Boehringer Ingelheim; Advisory/Consultancy, Research grant/Funding (institution), Travel/Accommodation/Expenses: Pfizer; Advisory/Consultancy, Research grant/Funding (self), Research grant/Funding (institution): AstraZeneca; Research grant/Funding (institution): Merck Sharp & Dohme; Research grant/Funding (institution): EMD Serono; Research grant/Funding (institution): Blueprint Medicines; Research grant/Funding (institution): Tesaro; Research grant/Funding (institution): Bavarian Nordic; Research grant/Funding (institution): Novartis; Research grant/Funding (institution): G1 Therapeutics; Research grant/Funding (institution): Adaptimmune; Research grant/Funding (institution): BMS; Research grant/Funding (institution): GSK; Research grant/Funding (institution): AbbVie; Research grant/Funding (institution): Rgenix; Research grant/Funding (institution): Roche; Research grant/Funding (institution): Genentech; Research grant/Funding (institution): Lilly; Research grant/Funding (institution), Travel/Accommodation/Expenses: Janssen; Travel/Accommodation/Expenses: E.R. Squibb Sons, LLC. All other authors have declared no conflicts of interest.

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