Abstract 1740P
Background
Coronavirus disease 2019 (COVID-19) outbreak is changing the approach of medical oncologists to cancer management. However, the real impact on cancer care and its potential negative consequences are currently unknown.
Methods
A 29-multiple choice question anonymous online survey was shared with members of the Italian Association of Medical Oncology and the Italian Breast Cancer Study Group on April 3, 2020. The objectives of the survey were to investigate the attitudes and practice of Italian oncologists before and during COVID-19 outbreak on three relevant areas in breast cancer care: 1) (neo)adjuvant setting; 2) metastatic setting; 3) research activities.
Results
The survey was completed by 165 oncologists, of whom 121 (73.3.%) worked in Breast Units. In the (neo)adjuvant setting, compared to before the emergency, a lower rate of oncologists adopted during COVID-19 outbreak weekly paclitaxel (68.5% vs. 93.9%, P<.001) and dose-dense schedule for anthracycline-based chemotherapy (43% vs. 58.8%, P<.001). In the metastatic setting, compared to before the emergency, a lower number of oncologists adopted during COVID-19 outbreak first-line weekly paclitaxel for HER2-positive disease (41.8% vs. 53.9%, P=.002) or CDK4/6 inhibitors for luminal tumors with less aggressive characteristics (55.8% vs. 80.0%, P<.001). A significant change was also observed in terms of delaying the timing for monitoring CDK4/6 inhibitors therapy, assessing treatment response with imaging and flushing central venous devices. Clinical research and scientific activities were reduced in 80.3% and 80.1% of respondents previously involved in these activities, respectively.
Conclusions
Most of the changes in the attitudes and practice of Italian oncologists were reasonable responses to the current health emergency without expected major negative impact on patients’ outcomes, although some potentially alarming signals of undertreatment were observed. These data invite developing cautious recommendations to help oncologists ensuring continuous effective and safe cancer care.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
F. Poggio: Travel/Accommodation/Expenses: Takeda; Honoraria (self), Travel/Accommodation/Expenses: Ely Lilly; Honoraria (self): Merck Sharp & Dohme; Novartis. M. Tagliamento: Travel/Accommodation/Expenses: Roche; Bristol-Myers Squibb; AstraZeneca; Takeda; Honoraria (self): Novartis. M. Di Maio: Research grant/Funding (institution): Tesaro GSK; Honoraria (self), Advisory/Consultancy: AstraZeneca; Janssen; Astellas; Eisai; Pfizer; Merck Sharp & Dohme; Takeda. L. Del Mastro: Advisory/Consultancy: Roche; Novartis; Eisai; Pfizer; AstraZeneca; Ipsen; Eli Lilly; MSD; Seattle Genetics; Genomic Health. M. Lambertini: Advisory/Consultancy: Roche; Honoraria (self): Theramex, Eli Lilly. All other authors have declared no conflicts of interest.