Abstract 71P
Background
Multidisciplinary treatment including neo-adjuvant/adjuvant chemotherapy, radical surgery, and radiation is challenging for super elderly patients (aged > 80 years old) with soft-tissue sarcoma because due to deterioration of physiological function/tolerance for chemotherapy and medical complications. The purpose of the present study was to clarify clinical outcomes of elderly patients aged > 80 years old with soft-tissue sarcoma (STS) who underwent surgery without neo-adjuvant nor adjuvant chemotherapy.
Methods
Twenty-three consecutive patients aged ≥ 80 years, who underwent surgical resections of STS between January 2013 and December 2022, were included. As prognostic factors, depth of the tumor, maximum diameter of the tumor, Geriatric Nutrition Index (GNRI) for geriatric status, High-sensitivity modified Glasgow Score (HS-mGSP) for inflammatory status, local recurrence, and distant metastasis were evaluated.
Results
The median age was 84 (range 80–91) years. The median follow-up period was 49 (range 6–119) months. Histological diagnoses were as follows: myxofibrosarcoma in 8 patients, undifferentiated pleomorphic sarcoma in 7 patients, dedifferentiated liposarcoma in 4 patients, leiomyosarcoma in 3 patients, and synovial sarcoma in 1 patient. The locations of the primary tumor were superficial in 13 patients and deep layer in 10 patients, respectively. All patients underwent surgical resections. R0 margins were achieved in all patients. The 1-, 2-, and 5-year disease-specific survival rates were 95.7%, 91.1%, and 85.%, (median 58 months). Univariate analysis showed local recurrence and distant metastasis may affect disease-specific survival (p < 0.05, respectively). GNRI and Hs-mGPS were not influenced on disease-specific survival. Multivariate logistic regression analysis showed that distant metastasis was independent risk factor for the disease-specific survival (p < 0.05).
Conclusions
In the current study, we observed a comparable survival rate, despite no neo-adjuvant or adjuvant chemotherapies performed. Tumor resections with adequate margins might, at least in part, have contributed to the decent survival ratio regardless of histological grade.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.