Abstract 115P
Background
Total femoral replacement is a remarkable breakthrough in the treatment of bone cancer, providing patients with an opportunity to avoid disability resulting from hip amputation and resume their normal daily activities. This procedure has been available worldwide since 1965, and its implementation has recently commenced in Vietnam, with 11 cases having been performed since 2020. The purpose of this study is to reassess the outcomes of the initial 11 cases of total femoral replacement conducted in Vietnam for the treatment of osteosarcoma.
Methods
A retrospective analysis study was undertaken to investigate 11 patients who underwent total femur replacement surgery as a result of osteosarcoma between March 2020 and May 2023.
Results
The male-to-female ratio was 4:7, with a mean age of 16.1 years old (range: 11-24 years old). All 11 cases were diagnosed with osteosarcoma. The average surgery time was 6 ± 1.5 hours, and the average blood loss was 1800 ± 500 ml. There are 3 indications for this surgery, and we found the highest failure rate in extremely large tumors in terms of tumor circumference. The lung metastasis group showed positive results, with 60% of patients achieving stable disease at the latest follow-up. After a mean follow-up of 17 months (range: 8-40 months), 9 patients were still alive, while 2 patients died from progressive disease. 2 cases experienced local recurrence of soft tissue disease, of which 1 case was resected, and one case required hip disarticulation. The Musculoskeletal Tumor Society (MSTS) score was 25/30, indicating good to excellent results. No complications were recorded during the follow-up period.
Conclusions
Our study shows that total femur replacement with artificial material is an effective treatment for osteosarcoma, which can significantly improve overall treatment outcomes and quality of life for patients with this condition, even with a lung metastasis group.
Clinical trial identification
Editorial acknowledgement
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Legal entity responsible for the study
T. Tran Duc.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.