Abstract 15P
Background
Struma ovarii, a rare form of teratoma with mature thyroid tissue, accounts for 2-5% of ovarian teratomas, with less than 5% exhibiting malignant transformation. Understanding the clinicopathological characteristics and prognostic factors in malignant struma ovarii (MSO) is crucial for informed clinical decision-making.
Methods
Data were obtained from the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2020. Patients who met any of the following criteria were excluded: diagnosis not confirmed by histology, not first tumor, and unknown data. Chi-square tests were used to compare clinicopathological features, while survival rates and prognostic factors were identified using the Kaplan-Meier estimator, log-rank tests, and Cox proportional hazard regression.
Results
In total, 329 patients were included. Most patients were 45 years or older (52.9%), and 42.9% had a tumor size of 40 mm or greater, with an average tumor size of 40.2 mm. years, with the predominant race being white (n=247). Most of the patients were in the localized stage (80.9%). Primary surgical resection was performed in 94.2% of the patients (n=310), 5.2% had undergone chemotherapy, and 13.4% were administered radiotherapy. After multivariate adjustment, older age, chemotherapy, and advanced stage of the primary tumor were found to be significant prognostic factors for adverse overall survival. In contrast, Asian ethnicity and surgery were good prognostic factors for overall survival.
Conclusions
Our study showed that surgical intervention alone can enhance overall survival rates in individuals with MSO. These findings offer significant information on MSO treatment and its prognostic factors for future clinical decisions. Additional research is necessary to confirm these results and explore any possible confounding variables that may have influenced the outcomes.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.