Abstract 32P
Background
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are uncommon cancers globally. The data on their clinical presentation, site of tumour and its grading, from India is scarce.
Methods
We retrospectively collected anonymised patient data from our electronic health records from 1st May 2011 to 1st Oct 2023. The information was initially collected in an excel sheet and then analysed for various parameters.
Results
We saw 418 patients with Neuroendocrine Neoplasms in our data set. Out of those, more than 81% (n=339) were GEP-NENs with male preponderance (Females=138). The median age of presentation for GEP-NENs was 60 years (Range: 12-90). Most common primary site of tumour was small intestine (37%, n=123) with maximum incidence in Pancreas (n=80) followed by Duodenum (n=72). Least common site was Esophagus/Gastroesophageal junction (n=5). With respect to tumour grading (WHO), we found G1 (125) G2 as most common (n=83) and G3 the least (n=50), information for 39% of tumours was not available, mostly because of inadequate tissue sample or incomplete review due to lack of follow up by the patients. Only 10 patients (3%) presented with carcinoid syndrome and most common symptom was diarrhoea (n=9). DOTA PET scan was done in about 44% (n=143) patients as initial imaging tool for staging. Half of the patients with GEP-NENs presented to our clinic with metastasis to various sites with liver being most common organ. About 19% patients had upfront Echocardiography to see for any carcinoid heart but only 1 patient was found to have hypertrophy of the right ventricle.
Conclusions
GEP-NENs are most common NENs observed. Small intestine is the most common site for GEP-NENs and it matches with the published global data. Carcinoid syndrome can be the presenting complaint, but we had less incidence.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.