Abstract 18P
Background
Malignant Brenner tumor is a rare histological subtype of epithelial ovarian cancer representing 1% of all ovarian tumors. The standard treatment is based on surgery but there are no available studies to compare the outcome of different surgery approaches for malignant ovarian Brenner tumor. Fertility-sparing surgery became preferred in oncologic gynecologic settings to preserve the ovarian tissue and the uterus. In addition, it can improve the sexual function and psychological wellbeing after cancer diagnosis and treatment. So this study aim is to evaluate the survival of fertility-sparing surgery versus radical hysterectomy in malignant Brenner tumor to support the limited current evidence on this rare type.
Methods
We used Surveillance, Epidemiology and End Results(SEER) program software to extract the data of 100 female patients with malignant Brenner tumor of the ovary diagnosed from 2000-2019. We divided them into two subgroups according to the surgery approach; fertility-sparing surgery (salpingo-oophorectomy without hysterectomy) and radical hysterectomy. We used SPSS for data analysis. Kaplan-Meier curve, Log-rank test for survival analysis.
Results
Out of 100 case, 82 had radical hysterectomy and 18 had fertility-sparing surgery. The overall 3-year and 5-year relative survival was (84.8% and 73.7%, respectively) while the 5-year survival outcome of fertility-sparing surgery and radical hysterectomy was (74.7% and 72.9%; P=0.7).
Conclusions
This study has a large sample for this rare type and the results showed fertility-sparing surgery had quiet similar survival outcome as radical hysterectomy which support fertility-sparing surgery to substitute radical hysterectomy for malignant Brenner ovarian tumor management for better quality of life for patients.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The author.
Funding
Has not received any funding.
Disclosure
The author has declared no conflicts of interest.