Abstract 78P
Background
Granulosa cell tumor (GCT) is a rare ovarian neoplasm characterized by its distinct histological features and variable clinical presentation. Despite being one of the most common sex cord-stromal tumors of the ovary, granulosa cell tumors remain relatively rare, contributing to a limited understanding of their incidence rates and trends, genetic predisposition, and clinical behavior which has resulted in under-developed guidelines for its screening and treatment. So, this study aims to add more evidence and data about this rare type.
Methods
Data of 1627 patients were extracted from the Surveillance, Epidemiological, and End Results (SEER) database diagnosed from 2000-2020. We analyzed age-adjusted trends and age-adjusted incidence rates. Rates are per 100,000 and age-adjusted to the 2000 US Std Population (19 age groups - Census P25-1130) standard; confidence intervals are 95% for rates (Tiwari mod) and trends. Percent changes were calculated using 1 year for each endpoint; APCs were calculated using weighted least squares method.
Results
The overall incidence rate was 0.1. The age-adjusted trends showed an annual percent change (APC) of 0.4 (95% CI -0.6 to 1.4), and percentage change (PC) of -4.7 with. This increase was among all ages, and races. When stratified by race from 2000 to 2020, Black, White, and Asian populations exhibited PCs of 21.7, -11.8, -79.6 respectively and APCs of 1.7 (95% CI: -0.4 to 3.8), -0.1 (95% CI -1 to 0.8), -0.7 (95% CI -4.6 to 3.3), and respectively.
Conclusions
Granulosa cell tumors showed poor overall survival. It showed an overall low incidence rate however, there is an expected increase in the next years as demonstrated by APC result. While the Black race exhibited an increasing incidence rate, Asian and White races showed decreasing rates. This expected increase in the incidence rate combined with poor survival outcomes of Granulosa cell tumors warrants the development of screening guidelines. We recommend focusing on the black race as they have the highest incidence rate.
Legal entity responsible for the study
The author.
Funding
Has not received any funding.
Disclosure
The author has declared no conflicts of interest.