Abstract 35P
Background
Ovarian malignancies are the 7th diagnosed malignancy and the 8th cause of death in females worldwide. Ovarian cancer includes a great heterogeneous group of neoplasms that differs in histological type, pathological stage, risk factors, prognosis, and treatment. Racial disparities in incidence, treatment, and mortality in cancers exist globally. With Surveillance, Epidemiology, and End Results (SEER) program in place, detection of these disparities would be feasible. herein racial disparities in ovarian cancer are analyzed.
Methods
Using SEER*Stat 8.3.9 program and then Case listing session and extracting data from Incidence - SEER Research Data, 13 Registries, Nov 2020 Sub (1992-2018). Patients with malignant behavior and known age diagnosed between 1992 to 2018 and site recode ICD-O-3 WHO 2008(ovary) were included; patients with incomplete data were excluded. Descriptive analysis and Kaplan Miere survival are done using IBM SPSS Statistics 25.
Results
46854 patients were included in the analysis, Non-Hispanic (NH) white race was 69.9% of them followed by the Hispanic group represents 11.8%. There was a great association between races and histology; eta was 0.06, Most predominant histological type was non-invasive low-grade serous carcinoma by 22.9%,20.7%,18.9% in NH white, Hispanic, NH black respectively. 2nd most predominant was Serous tubal intraepithelial carcinoma in NH American Indian/Alaska Native and NH Asian or Pacific Islander by 24.0% and 18.8% respectively. Kaplan Meier analysis revealed the best median survival time of 78 months (95%CI 70.89:85.12, SE 3.63) in NH Asian or Pacific Islander group, followed by Hispanic (All Races) with 56 months (95%CI 52.09:59.91, SE 1.99). The worst survival time was noticed in Non-Hispanic Black with a median survival time of 27 months (95%CI 24.95:29.05 SE 1.04). Log Rank p-value =0.001. Regarding Racial association with staging; eta was 0.04 and distant stage was predominant in all races 68.0%,68.7%,57.7%,67.1%,62.6% for NH White, NH Black, NH Asian or Pacific Islander, NH American Indian/Alaska Native, Hispanic (All Races) respectively.
Conclusions
Our analysis goes along with present literature regarding racial disparities.
Legal entity responsible for the study
The author.
Funding
Has not received any funding.
Disclosure
The author has declared no conflicts of interest.