Abstract 255P
Background
It is currently unclear whether the combination of neoadjuvant chemoradiotherapy (nCRT) and lateral lymph node dissection (LLND) improves survival in patients with rectal cancer suspected of lateral lymph node metastasis (LLNM) compared with LLND alone.
Methods
A retrospective analysis of clinical data from rectal cancer patients from January 2017 to November 2022 was conducted. Univariate and multivariate Cox regression analyses were performed on patients' clinical data, with a focus on identifying potential risk factors that affect disease-free survival (DFS) and overall survival (OS). Patients were divided into nCRT+LLND and LLND groups. Kaplan-Meier survival curves and log-rank test were used to analyse the survival outcomes of the different groups.
Results
The study included 92 patients. Univariate Cox regression analysis showed that intraoperative bleeding, pathological lateral lymph node metastasis (LLNM) and histological type were associated with DFS. When these factors were included in multivariate Cox regression, pathological LLNM was identified as an independent risk factor for reduced DFS. There were no statistically significant differences between the nCRT+LLND and LLND groups when comparing survival curves for both DFS and OS.
Conclusions
In rectal cancer cases with suspected LLNM, TME+LLND without nCRT may be a viable, yet to be validated, therapeutic strategy.
Legal entity responsible for the study
The authors.
Funding
Tianjin Key Medical Discipline (Specialty) Construction Project (NO: TJYXZDXK-044A).
Disclosure
All authors have declared no conflicts of interest.