Abstract 471P
Background
Gastric cancer is one of the neoplasms with higher incidence and mortality in the world and México. In patients with gastric cancer who underwent surgery, recurrence is the main cause of mortality. The present retrospective study aims to determine the clinicopathologic factors associated with recurrence and survival in patients with locally advanced gastric cancer (LAGC).
Methods
Clinicopathological data for patients who underwent curative resection for gastric cancer treated at the National Cancer Institute, between 2014 to 2023 were retrospectively analyzed. Pearson’s χ 2 test was used to compare differences between categorical variables. Statistical analysis was performed using SPSS V.26.
Results
We included 248 patients with LAGC who underwent curative resection, among them with median age of 56 (21 – 89) years and 52% males (n=129). Most patients underwent surgery initially (78.2%, n= 194) and had D2 lymphadenectomy (81.5%, n= 202); majority of lesions were found on the body (48.8%). Signet ring cells and grade 3 were detected in 50% (n= 124) and 76.2% (189) of tumors, respectively. According to the 8th edition American Joint Committee on Cancer (AJCC) staging system, most patients had stage III disease (55.6%, n= 138). Nearly half of all patients received adjuvant radiotherapy (57.3%, n=142) and most of patients received adjuvant chemotherapy (71.4%, n=177). Median disease-free survival was 29.29 months. 69% patients with LAGC had recurrence: 11.68% locoregional, 35.06% peritoneal and 53.2% distant non peritoneal recurrence. The factors associated with recurrence were chemotherapy regimen with cisplatin and fluorouracil (p=<0.001), stage III disease (p=< 0.001) and signet ring cells (p=0.015). Median global survival was 44.73 months and, in the same way, histology subtype, chemotherapy regimen and stage disease were the factors associated with mortality (cisplatin and fluorouracil, p=<0.001; stage III disease, p=< 0.001; and signet ring cells p=0.015). Adjuvant radiotherapy did not show a benefit in reducing recurrence nor survival.
Conclusions
In this study, we found that stage disease, chemotherapy regimen and signet ring cells were factors associated with recurrence and less survival.
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.