Abstract 334P
Background
Over half of pancreatic ductal adenocarcinomas (PDAC) recur within 12 months after curative intent resection. The aim of this systematic review and meta-analysis was to identify all reported prognostic factors for early recurrence in resected PDAC.
Methods
Following a systematic literature search, meta-analysis was conducted using a random-effects model. Separate analyses were performed for adjusted vs unadjusted effect estimates as well as reported odds ratios (OR) and hazard ratios (HR). Risk of bias was assessed using the QUIPS tool and evidence rated according to GRADE recommendations.
Results
After screening 2,903 abstracts, 65 studies were included. Twenty-eight (43.1%) studies defined early recurrence as evidence of recurrence within 6 months, while 34 (52.3%) defined it as evidence of recurrence within 12 months after surgery. Other definitions were uncommon. Analysis of unadjusted OR and HR revealed 41 and 5 prognostic factors for early recurrence within 6 months, respectively. When exclusively considering adjusted data, 25 and 10 prognostic factors were identified based on OR and HR, respectively. Using a 12-month definition, 38 (OR) and 15 (HR) prognostic factors were identified from unadjusted data and 38 (OR) and 30 (HR) prognostic factors from adjusted data, respectively. Based on frequency counts of adjusted data, preoperative CA19-9, N status, adjuvant therapy, grading, and tumor size based on imaging were identified as key prognostic factors for early recurrence.
Conclusions
Reported prognostic factors of early recurrence vary considerably. Identified key prognostic factors could aid in the development of a risk stratification framework for early recurrence. However, prospective validation is necessary.
Legal entity responsible for the study
Carl Leonhardt.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.