Abstract 95P
Background
Research on colorectal cancer patients with bladder invasion is scarce, and survival outcomes following cystectomy remain inadequately explored. The contentious choice between partial and total cystectomy persists.
Methods
This study enrolled 105 colorectal cancer patients with bladder invasion who underwent partial or total cystectomy at our hospital between December 2012 and April 2020. Surgical data and preoperative neoadjuvant information were collected. Groups were categorized based on the presence (+) or absence (-) of pathological bladder invasion, and 3-year overall survival (OS), 3-year recurrence-free survival (RFS), and 3-year local recurrence rates between the groups were compared.
Results
Among the 105 patients, 50 exhibited histologically confirmed bladder tumour invasion (diagnostic coincidence rate: 48%), comprising the bladder invasion (+) group. Of these, 94 patients underwent partial cystectomy, including 41 from the bladder invasion (+) group. In the bladder invasion (+) group, 3-year OS rates and RFS rates were 62.97% and 57.35%, respectively, with 3-year local recurrence (LR) and intravesical recurrence rates of 18.62% and 7.73%, respectively. In the bladder invasion (-) group, 3-year OS and RFS were 77.16% and 58.68%, respectively, with 3-year LR and intravesical recurrence rates of 25.83% and 11.82%, respectively. No significant differences were observed in 3-year OS and RFS between the groups (P > 0.05) or for 3-year LR and intracystial recurrence rates (P > 0.05). Nine patients experienced bladder recurrence at 6.5 to 13.5 months postoperation, and a colovesical fistula was identified preoperatively in four patients with bladder invasion (-). Univariate and multivariate Cox regression analyses revealed distant metastasis as an independent risk factor for OS and RFS in colorectal cancer with bladder invasion.
Conclusions
Positive pathological bladder invasion has not been established as an independent risk factor for OS among patients with colorectal cancer involving the bladder. Bladder and local recurrence risks persist following partial cystectomy, but the future adoption potential of partial cystectomy is promising.
Clinical trial identification
ChiCTR2300077861; Release date: 2023-11-22.
Legal entity responsible for the study
The authors.
Funding
National Natural Science Foundation of China (grant No. 82103084 to H. Wang).
Disclosure
All authors have declared no conflicts of interest.