Abstract 269P
Background
It is well known that inflammation is a hallmark of cancer perse and it is associated with progression, dissemination and worse outcomes in cancer patients. During daily practice Clinicians have few ways to determine the grade of inflammation in a cancer patient, due to basics of physiology we know that a neutrophil to Lymphocyte ratio (NLR) indicate the balance between immune and adaptive responses an it is an excellent indicator of inflammation together. The main objective was to determine an association of mortality and a high NLR (more than 2.5) in patients diagnosed with locally advanced rectal cancer at Instituto Nacional de Cancerlogia (INCan) in Mexico.
Methods
We have search information about patients with diagnosis of locally advanced rectal cancer in medical record. NLR were calculated from complete blood counts in laboratory test at diagnosis, cutoffs values for the NLR were > 2.5 and < 2.5, this cutoff value was reported in previous studies in population from Latinomerica. To analyze data, we used STATA V.14 and SPSS V.25, we have used the Kolmogorov Smirnov test to determine the normality of the variables, posterior to that we have used chi-square to associate the different variables with the mortality, and finally We have used Kaplan Mier test for survival analisis.
Results
From 2016-2021 358 patients were diagnosed with locally advanced rectal cancer. Mean age of diagnosis was 58 years, 48% were women and 52% were men, 8.7% were rectal cancers located in the upper third, 13.4% middle third, 49.7% lower third, upper and middle third 8.4%, middle and lower third 14.8 % and all three thirds 5%. We have found a association between mortality and the next variables: Neutrophils/lymphocytes ratio (NLR) (p 0.005), grade of tumor (p 0.004), pathologic complete response. Patients had a following of 8 years according to Kaplan Meier the survival at 80 months is 82 % for the patients with NLR less than 2.5 and the survival for patients with more than 2.5 is 69% (p 0.003).
Conclusions
Neutrophils/lymphocytic ratio is associated with higher mortality and worse overall survival in patients with locally advanced rectal cancer in Mexico.
Legal entity responsible for the study
M.D.C. Diaz Romero.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.