Abstract 204P
Background
Hepatocellular carcinoma (HCC) is considered a cancer with high mortality rates. Different treatment modalities have been used for it, including surgical resection and transplantation. Although treatment decision for HCC is multifactorial, suitable candidates often undergo surgery, whether it is liver resection or liver transplantation, however, which one is better is controversial. This study aimed to look at the effect of having prior malignancy on survival outcomes between the two surgeries.
Methods
The SEER database was used to identify patients diagnosed with hepatocellular carcinoma between 2000 and 2020, and then they were classified according to the kind of surgeries they had, whether it was a partial hepatectomy or liver transplantation. Kaplan-Meier curves and the log-rank test were used for survival analysis, which was conducted by SPPS v.27.
Results
10058 patients with HCC were included in this study, of which 1455 (14.5%) had a history of prior cancer. Among those who had a liver resection, there was a significant difference in 5-year age-standardized relative survival among patients with or without a prior history of cancer (p<0.001) with 49.9%, and 55.2%, respectively. However, no differences were observed for patients who underwent liver transplantation (p=0.272, with prior cancer 73.5%, without prior cancer 80.2%).
Conclusions
Although some studies suggested that the presence of prior cancer doesn't significantly contribute to worse outcomes, our findings revealed that primary HCC has a better survival outcome than subsequent HCC for patients who underwent partial hepatectomy. Regardless of prior cancer history, liver transplantation appears to offer consistent survival benefits for patients with HCC, which warrants further investigation. To optimize outcomes in HCC management, treatment approaches should be individualized based on patients' medical histories and prognostic factors.
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.