Abstract 266P
Background
Cancer is commonly diagnosed for elderly patients. However, worldwide increase incidence in patients between 20 and 49 years. In Kazakhstan since 2011 population- based screening for rectal cancer (RC).
Methods
descriptive study analyzed the proportion of patients early-onset cancer for 20-49 years and late-onset cancer for age 50 years and older of the total number of RC patients diagnosed in period 2006 – 2023 from Kazakhstan Cancer Registry. Annual percentage change (APC) was calculated by taking the difference in incidence between one year and the next and calculating the corresponding percentage. The average APC (AAPC) was obtained by adding all the APC and dividing by the total number of years of the study period.
Results
Of the 25,336 patients of both sexes with rectal cancer, 2,992 (11.8%) had early-onset cancer and 22,344 (88.2%) had late-onset cancer. Early-onset cancer in 1495 (11.5%) men and 1497 (12.1%) women. The average age of diagnosis of rectal cancer is 63.9 years, for men 63.6 years, and for women 64.3 years. The incidence of rectal cancer increased by 66.1%, for men by 78.4%, for women by 53.8%. When comparing 2023 rates to 2006, incidence increased by 1.5 times (47.3%) for early-onset cancers and 1.7-fold (68.9%) for late-onset cancers. In men, the incidence increased by 1.4 times (38.4%) for early-onset cancers, and 1.8-fold (84.4%) for late-onset cancers. In women, the incidence increased by 1.6 times (56.0%) for early-onset cancers, and 1.5 times (53.2%) for late-onset cancers. The mean annual percentage change (APC) increased by 3.5% for early-onset cancers and 3.3% for late-onset cancers. For men, AAPC increased by 2.8% for early-onset cancers and 3.9% for late-onset cancers. For women, AAPC increased by 5.9% for early-onset cancers and 2.7% for late-onset cancers. For cancer with early onset, the average dynamics is greater for men by 15.9% at the age of 35–39 years, for women by 23.4% at the age of 29–34 years. For late-onset cancers, there was a greater average change of 11.5% for men and women aged 85 years and older.
Conclusions
The mean annual percentage change for early-onset cancers increased. For the rectum by 2.8% for men and 5.9% for women.
Legal entity responsible for the study
Ministry of Healthcare of the Republic of Kazakhstan.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.