Abstract 307P
Background
Cholangiocarcinoma represents 3% of the gastrointestinal cancers. 65% are diagnosed at advanced stages of disease including clinical stages III and IV. Therapeutic approaches are limited. Due to the rareness of the disease, prognostic factors description remains unclear. This study aims to evaluate the impact of the inflammatory index on the prognosis of patients diagnosed with cholangiocarcinoma treated at the National Cancer Institute (INCan) Mexico.
Methods
Retrospective, observational study. Included patients treated at the INCan between 2014 and 2023. Statistical analysis required: X2 and t-test, Kaplan Meier, Log Rank, and Cox Regression. Statistical significance differences were assessed when p was bilaterally <0.05.
Results
A total of 222 patients were included in the analysis. 63% (n=140) were female, 84% (n=187) and the most frequent functional status was ECOG 2 (37.3%, n=83). 82% were adenocarcinoma (n=182), the most frequent clinical stage was IV (69%, n=153), with a prevalence of liver metastasis (51%, n=114). 46% (n=102) received chemotherapy, and 54% (n=150) had palliative care. Neutrophil/lymphocyte (INL), platelet/lymphocyte (IPL), neutrophil monocyte indices (IML), albumin, alkaline phosphatase (AF), and bilirubin were determined to evaluate their impact on prognosis. 69% had INL ≥3.15 mg/dl, 77% (n=171) IPL ≥106 mg/dl, and 79% (n=176) IML ≥0.24. Besides, 54% (n=119) had albumin ≥3.5 mg/dl, 71% (n=158) had AF ≥106 mg/dl, and 40% (n=89) had bilirubin ≥3.5 mg/dl. In overall survival (OS) analysis, patients with INL <3.15 had a median OS of 26m versus 11m (p=0.005), IPL <106 showed a median OS of 5m versus 3m (p =0.033), and IML <0.24 a median OS of 7m versus 3m (P= 0.014). Besides albumin 3.5 mg/dl had a median OS of 26m versus 10m (p=0.003), AF ≥106 mg/dl had a median OS of 50m versus 10m (p≤0.001), and bilirubin median OS of 17m (p=0.359). In uni-multivariate analysis, INL (p=0.030; HR 1.74, 95% IC 1.05 – 2.87) and AF (p=0.002; HR 0.35, 95% IC 0.18 – 0.67) remained predictor factors of OS.
Conclusions
In the prognosis assessment of this population, INL and AF remained predictor factors of OS. This is one of the first studies in Mexico to describe clinicopathological features and how these index correlates with the of OS of cholangiocarcinoma.
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.