Abstract 151P
Background
Metabolic syndrome (MetS) is linked to an increased risk of colorectal cancer (CRC), with various single-nucleotide polymorphisms (SNPs) associated with MetS. However, whether SNPs related to MetS are also associated with CRC risk has not been systematically addressed. To explore this, we conducted a cross-sectional case-control study within a Taiwanese population.
Methods
This cross-sectional study enrolled a total of 58,091 Taiwanese participants, including 1,206 patients with CRC, using data from the Taiwan Precision Medicine Initiative (TPMI) database at Taichung Veterans General Hospital. The study collected genotyping information using the Affymetrix TWB 2.0 genome-wide SNP Array. Selected 2129 MetS-associated SNPs from previous GWAS databases were compared with TPMI data. Subsequently, 43 SNPs were chosen for a case-control study, and unadjusted analyses were performed. Three SNPs (rs4923461, rs7395662, and rs13266634) showed significance. A total of 1,206 CRC subjects and 4,824 age-gender matched controls were assessed the association between SNPs and the risk of CRC was evaluated using logistic regression models.
Results
Among the 58,091 participants, 26,655 had no diagnosis of cancer or MetS, while 1,206 participants were diagnosed with CRC. The carrier ratios of the MADD-FOLH1 rs7395662 and SLC30A8 rs13266634 variants were significantly higher in CRC patients, at 72.5% and 73.37% respectively (p=0.015 and p=0.002). In contrast, the carrier frequency of BDNF-AS rs4923461 was significantly higher in participants without cancer or MetS (72.04%, p=0.010). Among these three SNPs, participants carrying the SLC30A8 rs13266634 G allele showed a significantly higher CRC risk (OR: 1.01, 95% CI: 1.004-1.195, p=0.040) compared to those with the A allele. No significant differences were found in terms of age, gender, smoking, alcohol consumption, tumor markers, tumor location, pathology, clinical staging, or mortality.
Conclusions
In this cohort study, we confirmed the importance of the SLC30A8 rs13266634 G allele with an increased risk of CRC. The pleiotropic effects of this SNP on both MetS and CRC risk offer valuable insights for precision health strategies.
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.