829P - Flumatinib combined with chemotherapy for newly diagnosed adult with Ph-positive acute lymphoblastic leukemia: A single-center, retrospective observational study

Background

Outcomes in patients with Philadelphia chromosome positive (Ph+) acute lympho blastic leukemia (ALL) have improved with the use of tyrosine kinase inhibitors (TKIs).

Methods

This was a single-center, retrospective observational study conducted on patients with newly diagnosed Ph+ ALL patients who received flumatinib combined with multiagent chemotherapy as treatment regimen between April 2020 to May 2023. Patients were followed up by electronic medical record system and by telephone until 14 November 2023.

Results

A total of 48 adults with newly diagnosed Ph+ALL were enrolled, including 25 males and 23 females. The median age was 40 years. After the administration of flumatinib combined with multiagent chemotherapy, the induced complete remission (CR), 3 month CR, and 6 month CR rates achieved 97.9%, 100%, and 93.3%, respectively. The rate of minimal residual disease negative (MRD-) by flow cytometry was 59.3%, 81.3%, 95.1%, and 90.0% in 0.5, 1, 3, and 6 months, respectively. The rates of major molecular response (MMR) were 54.6%, 61.4%, 82.0%, and 89.3% in 0.5, 1, 3, and 6 months after treatment, respectively. While the rates of complete molecular response (CMR) were 50.0%, 43.2%, 64.1%, and 85.7%. With a median follow-up of 41.1 months, the 3 years overall survival (OS), progression-Free Survival (PFS) and event free survival (EFS) were 70.8%, 62.5% and 45.8%, respectively. 35.42% (17/48) patients were administered allogeneic SCT. The OS of patients with SCT was significantly better than patients without SCT (94.1% vs. 54.8%, p=0.0057). The OS of patients by CR after induction therapy significantly prolonged (70.21% vs. 0, p = 0.0001). The OS of patients with MRD-negative was remarkably better than patients MRD-positive (71.79% vs. 55.56%, p＜0.0001). The OS of patients whether they had achieved MMR and CMR suggested no impact on OS. 64.1%(25/39) patients received a CMR in 3 months after treatment, the OS of patients whether had achieved CMR revealed no statistical difference(68% vs. 78.57%, p=0.4618).

Conclusions

Flumatinib combined with multiagent chemotherapy as induction had a high level of efficacy in adult with newly diagnosed Ph+ ALL patient.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

The Basic Research and Cultivation Fund for Young Teachers of Zhengzhou University.

Disclosure

All authors have declared no conflicts of interest.