Abstract 1584P
Background
The impact of TB (which contributes to both financial and time toxicities) on cancer treatment and outcomes, especially in RLS remains largely understudied. We assessed the impact of TB on the outcomes of patients with CRC treated at a regional cancer center in RLS.
Methods
All patients with newly diagnosed CRC in 2022 at the State Cancer Institute, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, North India were enrolled. TB was recorded as the average time required to traverse the shortest distance between the cancer center and the place of the patient’s residence.
Results
263 patients (42.6% females) with CRC were included, including patients who travelled from their homes (group A) and those who rented apartments near the hospital to complete treatment (group B). Group A patients (N=178) travelled 22 km (48 mins) [median] to reach the cancer center while Group B patients (N=85) resided 75 km (130 mins) [median] away from the hospital. Travel time did not correlate with symptom duration prior to diagnosis of CRC. In group A, patients with highest TB (Q4 travel time) had poorer outcomes than other patients (Q1-Q3 of travel time) (18-month OS of 65% v 83.6%, adjusted HR 2.5 [95% CI 1.2 to 5.2]) (Table). 18-month OS in group B was higher than that for group A patients (85.6% v 78.9%, p=0.056). Table: 1584P
Predictors of OS in patients with CRC [data expressed as HR (95% CI), p-value]
| Parameter | Group A | Group B | ||
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |
| 1. Age ≥50 years | 1.6 (0.8 to 3.5), 0.2 | 1.3 (0.3 to 6.4), 0.8 | ||
| 2. Female sex | 0.8 (0.4 to 1.5), 0.4 | 0.5 (0.1 to 2.3), 0.3 | ||
| 3. Presence of comorbidity | 1.1 (0.5 to 2.1), 0.8 | 0.0 (0.0 to 8.0), 0.2 | ||
| 4. ECOG >1 | 3.6 (1.7 to 7.5), 0.001 | 3.4 (1.4 to 7.9), 0.005 | 0.8 (0.1 to 6.7), 0.9 | |
| 5. Left vs right colon | 1.3 (0.5 to 3.5), 0.6 | 1.6 (0.12 to 13.4), 0.7 | ||
| 6. Metastatic disease | 8.1 (4.0 to 16.2), ConclusionsOur study demonstrates that TB is significantly associated with poorer outcomes in patients with CRC. Clinical trial identificationEditorial acknowledgementLegal entity responsible for the studyS.Z. Banday. FundingHas not received any funding. DisclosureB. Gyawali: Financial Interests, Personal, Writing Engagement, For writing Medscape Columns: Medscape; Financial Interests, Personal, Invited Speaker, For giving invited talks and grand rounds at universities, cancer centers and professional societies: Various academic and professional organizations; Financial Interests, Personal, Other, Consulting services: Vivio Health; Non-Financial Interests, Member: ASCO, IASLC, JSMO. All other authors have declared no conflicts of interest. Resources from the same session1563P - Increasing the earlier detection of lung cancer: A toolbox for changePresenter: Helena Wilcox Session: Poster session 10 1564P - Limited participation in breast cancer screening among low-SES women: A matter of engagement or of health literacy?Presenter: Allegra Ferrari Session: Poster session 10 1566P - Optimizing participation in lung cancer screening program: Results from the first round in ILYAD study in Lyon University HospitalPresenter: Emmanuel Grolleau Session: Poster session 10 1567P - Physicians' adenoma detection rate and the risk of colorectal cancer in sequential screening programs: An observational cohort studyPresenter: Li Xie Session: Poster session 10 1568P - Challenges in pilot lung cancer screening in Vojvodina, SerbiaPresenter: Jelena Djekic Malbasa Session: Poster session 10 1569P - Secondary delay in breast cancer diagnosis and role of rural medical practitioners: A cause and cure finding studyPresenter: Rahul Agarwal Session: Poster session 10 1570P - Factors and impacts of delayed presentation for county-level patients with breast cancer in a real-life setting in ChinaPresenter: Yinghua Ji Session: Poster session 10 1571P - The reasons that motivate a change of specialties among oncology residentsPresenter: Christophe Ducrocq Session: Poster session 10 1572P - Factors associated with career choice in oncology among medical studentsPresenter: Nicolas Penel Session: Poster session 10 This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. For more detailed information on the cookies we use, please check our Privacy Policy.
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