Abstract 1584P
Background
The impact of TB (which contributes to both financial and time toxicities) on cancer treatment and outcomes, especially in RLS remains largely understudied. We assessed the impact of TB on the outcomes of patients with CRC treated at a regional cancer center in RLS.
Methods
All patients with newly diagnosed CRC in 2022 at the State Cancer Institute, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, North India were enrolled. TB was recorded as the average time required to traverse the shortest distance between the cancer center and the place of the patient’s residence.
Results
263 patients (42.6% females) with CRC were included, including patients who travelled from their homes (group A) and those who rented apartments near the hospital to complete treatment (group B). Group A patients (N=178) travelled 22 km (48 mins) [median] to reach the cancer center while Group B patients (N=85) resided 75 km (130 mins) [median] away from the hospital. Travel time did not correlate with symptom duration prior to diagnosis of CRC. In group A, patients with highest TB (Q4 travel time) had poorer outcomes than other patients (Q1-Q3 of travel time) (18-month OS of 65% v 83.6%, adjusted HR 2.5 [95% CI 1.2 to 5.2]) (Table). 18-month OS in group B was higher than that for group A patients (85.6% v 78.9%, p=0.056). Table: 1584P
Predictors of OS in patients with CRC [data expressed as HR (95% CI), p-value]
| Parameter | Group A | Group B | ||
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |
| 1. Age ≥50 years | 1.6 (0.8 to 3.5), 0.2 | 1.3 (0.3 to 6.4), 0.8 | ||
| 2. Female sex | 0.8 (0.4 to 1.5), 0.4 | 0.5 (0.1 to 2.3), 0.3 | ||
| 3. Presence of comorbidity | 1.1 (0.5 to 2.1), 0.8 | 0.0 (0.0 to 8.0), 0.2 | ||
| 4. ECOG >1 | 3.6 (1.7 to 7.5), 0.001 | 3.4 (1.4 to 7.9), 0.005 | 0.8 (0.1 to 6.7), 0.9 | |
| 5. Left vs right colon | 1.3 (0.5 to 3.5), 0.6 | 1.6 (0.12 to 13.4), 0.7 | ||
| 6. Metastatic disease | 8.1 (4.0 to 16.2), ConclusionsOur study demonstrates that TB is significantly associated with poorer outcomes in patients with CRC. Clinical trial identificationEditorial acknowledgementLegal entity responsible for the studyS.Z. Banday. FundingHas not received any funding. DisclosureB. Gyawali: Financial Interests, Personal, Writing Engagement, For writing Medscape Columns: Medscape; Financial Interests, Personal, Invited Speaker, For giving invited talks and grand rounds at universities, cancer centers and professional societies: Various academic and professional organizations; Financial Interests, Personal, Other, Consulting services: Vivio Health; Non-Financial Interests, Member: ASCO, IASLC, JSMO. All other authors have declared no conflicts of interest. Resources from the same session1481P - A case-control study of drug-eluting microspheres and blank microspheres in bronchial artery embolization for hemoptysis in non-small cell lung cancerPresenter: Tongguo Si Session: Poster session 10 1482P - Percutaneous transhepatic biliary drainage (PTBD) for palliation of jaundice in patients of unresectable/disseminated carcinoma gall bladder with hilar block: Is it a worthwhile enterprise?Presenter: Saurabh Galodha Session: Poster session 10 1484P - Inflammatory patterns of ascites in patients with solid tumorsPresenter: Julia Berger Session: Poster session 10 1485P - Mitigating symptom clusters of patients with metastatic cancer through a remote physical exercise program (EXIO)Presenter: Paulo Bergerot Session: Poster session 10 1486P - A personalized rehabilitation pilot program for improving QOL of unresectable metastatic lung cancer patientsPresenter: Shani Shilo Session: Poster session 10 1487P - Telemonitoring system effectiveness for alleviating cancer pain in patients with advanced cancerPresenter: Shiori Yoshida Session: Poster session 10 1488P - Use of mobile app “SUPPORT+” to enhance community palliative care in advanced cancer patients: A feasibility studyPresenter: Wendy Chan Session: Poster session 10 1489P - Factors influencing adherence to electronic patient-reported outcomes in palliative cancer carePresenter: Sarah Gomes Session: Poster session 10 1490P - Health-related quality of life of cancer patients on chemotherapy and its relationship with caregiver strain: A cross-sectional analytical studyPresenter: Herald Mapa Session: Poster session 10 Resources: Abstract This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. For more detailed information on the cookies we use, please check our Privacy Policy.
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