824O - Treatment and survival in patients with localized primary ocular adnexal MALT lymphoma: A large bicentric cohort study

Background

Despite the generally favorable prognosis of POAML, There is limited understanding of the extent to which primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (POAML) impacts a patient’s risk of death and how different treatment managements affect prognosis and toxicities in this specific MALT site.

Methods

This study analyzed major long-term outcomes of patients with POAML lymphoma and the prognostic significance of baseline clinical features. We reviewed the clinical features, treatments, disease course and long-term outcome of 262 patients with Ann-Arbor stage IE POAML diagnosed between 2000 to 2012. Outcomes were analyzed using crude overall survival (OS) and relative survival (RS) by standardized mortality ratio (SMR). A cross-sectional study was conducted using OSDI questionnaires to evaluate the long-term ocular adverse effects.

Results

The median age was 55 years. With a median follow-up of 66 month, the 5-year OS, lymphoma-specific mortality and competing non-lymphoma mortality were 96.8%, 0.4% and 2.3%, respectively, and the estimated 10-year corresponding rates were 90.0%, 0.4% and 4.2%; the overall SMR was 1.02 (95% confidence interval [CI]: 0.60-1.61, P = 0.963). The OS and RS rates were similar across the treatment groups; however, RT associated with significantly decreased risks of failure (11.0%, n = 82, p = 0.006), compared to observation (33.3%, n = 81), surgery (28.6%, n = 70), and CT/IT groups (24.1%, n = 29). The cross-sectional study indicated that RT wasn’t obviously increased the intermediate-severe grades of dry eye diseases for a relative long-time after treatment.

Conclusions

Overall, a diagnosis of stage IE POAML lymphoma had similar long-term survival to the general population. RT associated with lower failure rates and minor ocular adverse effects.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.