Abstract 5P
Background
Tertiary Lymphoid Structures (TLS) mediate local antitumor immunity. Since cancer immunotherapy, TLS interests grown considerably. We examined TLS and tumor stromal blood vessels for BC molecular subtypes associated with recurrence, lymphovascu-lar (LIV), and perineural invasion (PnI).
Methods
CD34/SMA double immunostaining revealed TLS high endothelial venules and BC tumor stromal immature and mature blood vessels. Statistical study linked microscopic data to recurrence, LIV, and PnI.
Results
TLS- subgroups have higher LIV, PnI, and recurrence (p<0.001), except for Luminal A type. LIV and PnI rise in HER2+/TLS- subgroups (p<0.001). TNBC/TLS- had the highest recurrence and invasion risks. TNBC/TLS- subgroup recurrence is related to tumor grade and LIV/PnI (p<0.001), unlike other TLS- subgroups. PnI but not LVI are related with TNBC/TLS+ subgroup recurrence (p<0.001).
Conclusions
TLS affect BC molecular subtype recurrence, LVI, and PnI differently. Its antitumor immunity mediator seems closely associated to tumor aggressiveness and stromal blood vessels.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
25P - Role of AXL activation on adaptive resistance to KRAS-G12C inhibitors in KRAS-G12C-mutated non-small cell lung cancer
Presenter: Tadaaki Yamada
Session: Poster session 09
26P - Pre-clinical modelling and treatment of BRAF mutated colorectal cancer
Presenter: Mark White
Session: Poster session 09
27P - Extending a classification system for atypical BRAF mutations to improve targeted therapies in colorectal cancer cells
Presenter: Abhinav Madduri
Session: Poster session 09
28P - Xanthine oxidase as a prognostic factor in colorectal cancer metastatic disease
Presenter: Anton Burlaka
Session: Poster session 09
29P - The effect of cancer associated fibroblast-derived activin A on colorectal cancer progression
Presenter: Simone Stang
Session: Poster session 09
30P - Prostaglandin signaling in tumour stroma interaction in colorectal cancer and its impact on the secretome and functional relevance
Presenter: Mario Macia-Guardado
Session: Poster session 09
31P - Cell-free tumor microRNA as early biomarkers of high-grade cervical intraepithelial neoplasia using liquid biopsy
Presenter: Stéphanie Calfa
Session: Poster session 09
32P - Epigenetic reprogramming induced prostaglandin E2 accumulation via overactivated arachidonic acid metabolism during trastuzumab resistance formation of HER2-positive breast cancer
Presenter: yongmei yin
Session: Poster session 09
33P - Visualizing trastuzumab-deruxtecan action in HER2+ breast cancer cells at nanoscale
Presenter: Katia Cortese
Session: Poster session 09
35P - SAT-122: A potential first-in-class, potent, small-molecule disruptor of RAD51-BRCA2, attenuates RAD51 foci formation and tumor progression in preclinical models
Presenter: Sukanya Patra
Session: Poster session 09