Abstract CN71
Background
Approximately 50% of women receiving chemotherapy for breast cancer develop chemotherapy induced peripheral neuropathy (CIPN) and is associated with significant disability and poor recovery. Common symptoms of CIPN include pain, altered sensation, reduced or absent reflexes, muscle weakness, reduced balance control and insecure gait. These symptoms affect activities of daily living and reducing patients' quality of life. CIPN also cause treatment delays, dose reductions, or even discontinuation of therapy, which can affect the outcome and compromise survival. To date, CIPN cannot be prevented and effective treatment options are lacking. Preliminary data indicate that whole body vibration (WBV) exercise may have a preventive effect on the onset of CIPN. However, how WBV compares to conventional cardio and resistance exercise (CAR) exercise for alleviate CIPN has not yet been studied. The aim is to compare the effects of WBV exercise compared to CAR on the primary outcome of CIPN symptoms and secondary outcomes of balance, physical function, and quality of life.
Methods
This prospective, multicenter, two-armed, randomized pilot study will include 44 women, assigned randomly either to the WBV group or the CAR group. Patients will exercise twice per week (at Karolinska) for 12 weeks. Measurements are performed at baseline, 3 and 6 months. Inclusion criteria: breast cancer diagnosis, aged 18–65 years, ECOG performance status of 0–2, completed chemotherapy in the past 6 month and remaining CIPN symptoms. Exclusion criteria: pre-existing neuropathy of other cause, severe cardiovascular disease, regular intake of analgesics, smoking. Measurement: CIP-NAT, CIPN-R-ODS, QLQ-C30, PainDETECT, Monofilament, Turn fork test, Tendon reflexes, Balance and Muscle strength tests.
Results
Based on previous study findings, we hypothesize that WBV exercise compared to CAR will reduce symptoms to a larger degree, such as the loss of peripheral deep sensitivity, pain, weakened or absent reflexes and loss of balance control.
Conclusions
Hopefully patients will experience an improvement in physical function and quality of life.
Clinical trial identification
NCT05361018.
Editorial acknowledgement
Legal entity responsible for the study
Y. Wengström.
Funding
Swedish Breast Cancer Association.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
CN75 - Validation of a symptom diary for outpatients with cancer receiving intravenous chemotherapy and/or targeted therapy
Presenter: José Koldenhof
Session: Poster session 25
Resources:
Abstract
CN86 - Advanced breast cancer care for nurses (ABC4Nurses): A mixed-methods evaluation of an online educational programme
Presenter: Sarah Sheehan
Session: Poster session 25
Resources:
Abstract
CN87 - An accreditation tool towards safe quality cancer nursing care
Presenter: Fernanda Conceição
Session: Poster session 25
Resources:
Abstract
CN88 - Handling cancer drugs: Inventory of the state of knowledge and educational opportunities in Sweden
Presenter: Anki Delin Eriksson
Session: Poster session 25
Resources:
Abstract
CN89 - In cancer care nursing, does the use of surface wipe sampling for hazardous drugs lead to a safer occupational environment, in an outpatient and inpatient oncology/haematology setting? An evidence translation proposal
Presenter: Audrey O'Halloran
Session: Poster session 25
Resources:
Abstract
CN90 - Managing the increasing capacity pressures in a nurse-led rural, satellite oncology unit in the era of immunotherapy
Presenter: SANDRA MURPHY
Session: Poster session 25
Resources:
Abstract
CN91 - Mentors' roles and responsibilities expected by nursing students in clinical training at the institute of oncology Ljubljana, Slovenia
Presenter: Miladinka Matković
Session: Poster session 25
Resources:
Abstract
CN92 - Nursing students’ attitude towards care of dying: A cross-sectional study in Italy
Presenter: Mayra Veronese
Session: Poster session 25
Resources:
Abstract
CN93 - Strategic patient collaboration, cancer theme Karolinska comprehensive cancer center (CCC)
Presenter: Ann-Britt Johansson
Session: Poster session 25
Resources:
Abstract
CN94 - The effect of a compassion fatigue resiliency program on oncology-hematology nurses' professional quality of life, stress levels and patients' care satisfaction: Nurse, patient and nurse manager’s perspectives
Presenter: Tugba Pehlivan Sarıbudak
Session: Poster session 25
Resources:
Abstract