346P - Quality of life (QoL) and toxicity in patients (pts) with hormone receptor-positive, HER2-negative early breast cancer (HR+, HER2– eBC) treated with adjuvant (adj) endocrine therapy (ET) in the CANcer TOxicities (CANTO) study

Background

ET is the mainstay treatment (tx) for HR+ eBC but they have persistent side effects that negatively affect QoL, leading to early tx discontinuation and compromising outcomes. We describe the incidence of ET toxicity and its QoL impact in CANTO.

Methods

CANTO (NCT01993498) is a prospective, longitudinal cohort study enrolling pts with invasive (cT0-cT3, cN0-3, no metastases) BC from 26 French cancer centres. Pts with HR+, HER2– eBC treated with adj ET were followed for the first 3 years (yrs) after eBC diagnosis. Pt demographics, clinical data, adherence, symptoms and QoL were collected. Questionnaires were administered at baseline (BL), 3–6 months (mo; M0) after primary surgery, chemotherapy or radiotherapy completion (whichever came last), and 12 mo, 36 mo and 60 mo after M0. Descriptive analyses were conducted for frequency of symptoms and mean/median QoL questionnaires summary scores.

Results

Of the 5564 pts who met the inclusion criteria (median age: 57 yrs), 63% were post-menopausal and 52% had stage I eBC at diagnosis. The table shows QoL and toxicity data. Global and functioning QoL remained high at BL and during tx. BC-specific symptoms persisted during tx. Pain was the most prevalent toxicity in the first 3 yrs; prevalence of muscular and joint pain increased over time. Mean intensity of global, muscular and joint pain all remained high over the course of ET (median intensity: ∼6 [0–10 scale]). ET adherence was 81–93% over time; in the first 3 yrs, 23% switched ET and 7% discontinued adj ET; toxicity was the main reason cited. Table: 346P

Conclusions

While global and functional QoL remained high in the first 3 yrs after eBC diagnosis, BC-specific symptoms slightly increased/persisted during ET. This study confirmed long-term toxicity of ET, particularly pain. Better management of symptoms and supportive interventional strategies are needed to further improve QoL in eBC.

Clinical trial identification

NCT01993498, first posted November 25, 2013.

Editorial acknowledgement

Research support for third-party writing assistance for this abstract, furnished by Eleanor Porteous, MSc, of Health Interactions, was provided by F. Hoffmann-La Roche Ltd, Basel, Switzerland.

Legal entity responsible for the study

F. Hoffmann-La Roche Ltd.

Funding

F. Hoffmann-La Roche Ltd.

Disclosure

A. Bertaut: Non-Financial Interests, Personal, Other, Research funding: Support for third-party writing assistance from F. Hoffmann-La Roche Ltd: F. Hoffmann-La Roche Ltd. T. Badovinac Crnjevic: Financial Interests, Personal, Full or part-time Employment: F. Hoffmann-La Roche Ltd/ Genentech; Financial Interests, Personal, Stocks/Shares: F. Hoffmann-La Roche Ltd; Non-Financial Interests, Personal, Other, Research funding: Support for third-party writing assistance from F. Hoffmann-La Roche Ltd: F. Hoffmann-La Roche Ltd. A. Martin, C. Gaudin: Non-Financial Interests, Personal, Other, Research funding: Support for third-party writing assistance: F. Hoffmann-La Roche Ltd. L. Chen: Financial Interests, Personal, Full or part-time Employment: Genentech, Inc.; Financial Interests, Personal, Stocks/Shares: F. Hoffmann-La Roche Ltd; Non-Financial Interests, Personal, Other, Research funding: Support for third-party writing assistance: F. Hoffmann-La Roche Ltd.