Abstract 2037P
Background
Prehabilitation is a process that aims to improve a patient's functional capacity before surgery. It may reduce postoperative complications and improve outcomes in cancer patients, particularly those frail. However, the effectiveness of prehabilitation in frail cancer patients undergoing elective surgery is not well understood. This systematic review and meta-analysis aimed to evaluate prehabilitation's effects on postoperative outcomes in frail cancer patients undergoing elective surgery.
Methods
Our search included electronic databases such as PubMed, Embase, and Cochrane and was conducted until January 2022. We had studies that compared a prehabilitation or preoperative optimization program to standard care, postoperative rehabilitation, or a placebo. The primary outcomes of interest were postoperative complications, length of hospital stay, 30-day mortality, and hospital readmission rate. We used R version 4.0.3 and the metafor and meta packages for statistical analysis.
Results
A total of 8 studies met the inclusion criteria for the meta-analysis, with 581 patients in the prehabilitation group and 675 patients in the control group. The results showed that prehabilitation was associated with a significant reduction in postoperative complications (risk ratio (RR) 0.83, 95% confidence interval (CI) 0.69 to 0.98). Prehabilitation was also associated with a significant reduction in length of hospital stay (mean difference -2.32 days, 95% CI -4.34 to -0.29) and a non-significant reduction in 30-day mortality (RR 0.45, 95% CI 0.13 to 1.59). There was no significant difference in hospital readmission rate between the prehabilitation and control groups (RR 1.09, 95% CI 0.38 to 3.15).
Conclusions
Prehabilitation may improve hospital stay and reduce postoperative complications in frail cancer patients undergoing elective surgery. Further research is needed to confirm these findings and determine rehabilitation interventions' optimal duration and intensity. Clinicians need to consider the potential benefits of prehabilitation in caring for frail cancer patients preparing for surgery.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
2106P - Safety and patient reported outcomes of SARS-CoV-2 vaccination in patients with cancer
Presenter: Amy Body
Session: Poster session 06
2107P - Thromboprophylaxis with intermediate or prophylactic doses of LMWHs in ambulatory cancer patients
Presenter: Nikolaos Tsoukalas
Session: Poster session 06
2108P - Vitamin B12 and its clinical relevance in hospitalized cancer patients
Presenter: Stefano Maccarone
Session: Poster session 06
2109P - Vitamin A, D and E levels in patients with solid tumors undergoing palliative systemic cancer treatment
Presenter: Julia Berger
Session: Poster session 06
2111P - The value of multiple psychometric tools for distress screening and referral in a cancer population
Presenter: Daniel Anderson
Session: Poster session 06
2112P - Initial geriatric assessment and chemotherapy tolerability treatment in Brazilian patients with malignant neoplasm of the digestive system
Presenter: Marcos Dumont Bonfin Santos
Session: Poster session 06
2113P - Efficacy and effectiveness of prophylactic magnesium supplementation on prevention of cisplatin-induced nephrotoxicity: A systematic review and meta-analysis
Presenter: Caio Castro
Session: Poster session 06
2114P - Impact of comprehensive geriatric assessment (CGA) in the management of chemotherapy toxicity in older cancer patients
Presenter: Jordi Recuero-Borau
Session: Poster session 06
2115P - Pre-cachexia incidence in patients with solid cancer: A cross-sectional study
Presenter: Lynn Gottmann
Session: Poster session 06