Abstract 1666P
Background
The GARIBALDI study investigated the impact of oncology center volume, type, and accrual rate on the prognosis of the overall therapeutic management of patients (pts) with non-metastatic Pancreatic Ductal Adenocarcinoma (nmPDAC).
Methods
Consenting treatment-naïve pts ≥ 18-year with pathological diagnosis of nmPDAC were eligible. Participating centers were categorized according to the self-declared expertise, the type and the accrual rate. Survival curves were estimated by the Kaplan–Meier method and compared by the log-rank test. Overall Survival (OS) was defined as the time from the date of medical therapy start to death for any cause.
Results
Between July 2017 and October 2019, 402 pts with nmPDAC from 44 centers were enrolled. Median age was 69 (range 36-89); 50% females; 93% ECOG PS 0-1; 33% overweight/obese; 17%, 38.7%, 44.3% with stage I, II, III, respectively; median CA19.9 177 (range 0-350,933); 17% with prior cancer history. Median diagnosis to treatment interval was 26 days. 68.4% had baseline CT >25 days before treatment start. 64% received chemotherapy upfront mainly consisting of nab-paclitaxel+gemcitabine (55%), gemcitabine alone (12%) or FOLFIRINOX (27%); 50% were submitted to surgery; 32% received radiotherapy. The median follow-up was 43.7 months and 274 pts died. The table provides the median OS estimates.
Table: 1666P
Deaths/N | Overall survival (Median [95%CI]) | Log-rank p-value | |
Self-declared expertise | 0.0036 | ||
Low-volume (<25 pts/year) | 46/61 | 15.5 [11.7-21.8] | |
Medium-volume (25-50 pts/year) | 48/69 | 21.6 [16.9-24.5] | |
High-volume (>50 pts/year) | 174/260 | 23.2 [19.2-27.1] | |
Type | 0.0714 | ||
Community hospitals | 108/154 | 20.6 [16.6-23.2] | |
Academic centers | 166/248 | 22.0 [18.7-26.9] | |
Accrual rate | 0.0238 | ||
Low-accrual (<10 pts/year) | 114/161 | 18.7 [15.8-23.6] | |
Medium-accrual (10-50 pts/year) | 107/149 | 21.6 [18.6-25.1] | |
High-accrual (> 50 pts/year) | 53/92 | 29.3 [18.1-35.6] |
Conclusions
A statistically significant difference in OS was found based on center volume and accrual rate, while a clinical difference was highlighted based on center type.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Associazione Italiana di Oncologia Medica (AIOM).
Funding
Celgene S.r.l.
Disclosure
C. Pinto: Financial Interests, Institutional, Funding: Eli Lilly, Bayer, Roche; Financial Interests, Personal, Advisory Board, DSMB: BMS, Eli Lilly, Novartis and Merck; Financial Interests, Personal, Advisory Board: Novartis, BMS, Amgen. M. Milella: Financial Interests, Personal, Advisory Board: AstraZeneca, MSD, Pfizer, Merck, Novartis, Ipsen, Viatris; Financial Interests, Personal, Steering Committee Member: Novartis; Financial Interests, Institutional, Funding: Roche. F. Bergamo: Financial Interests, Personal, Invited Speaker: Lilly, BMS, MSD, EISAI, Bayer; Financial Interests, Personal, Advisory Board: Servier, AAA; Other, Other, congress: Bayer, Ipsen, AAA. M.C. Di Marco: Financial Interests, Personal, Advisory Board, DSMC: OncoSil. G.G. Cardellino: Financial Interests, Personal, Other, Attending Meeting and/or travel: Incyte, Eli Lilly, Amgen, MSD; Financial Interests, Personal, Advisory Board: Eli Lilly, MSD, AstraZeneca. L. Cavanna: Financial Interests, Personal, Other, Consulting fees: AstraZeneca, Merck; Financial Interests, Personal, Other, Support for attending meetings and/or travel: Pfizer, Ipsen, Celgene. E. Giommoni: Financial Interests, Personal, Invited Speaker: Viatris, Amgen, AstraZeneca; Financial Interests, Personal, Advisory Board: Viatris, Amgen, Viatris, Ipsen. M. Reni: Financial Interests, Institutional, Funding: AstraZeneca; Financial Interests, Personal, Advisory Board, and DSMC: Eli Lilly, Panavance, Celgene, AstraZeneca, Viatris, Merck Sharp & Dohme, Servier, Sotio, Baxter. All other authors have declared no conflicts of interest.
Resources from the same session
1664P - Italian Association for Medical Oncology (AIOM) guideline application in real-world: Multi-institutional based survey of adjuvant and first-line pancreatic ductal adenocarcinoma treatment in Italy (GARIBALDI) - survival analyses in the metastatic cohort
Presenter: Michele Reni
Session: Poster session 22
1665P - Prognostic impact of diabetes and antidiabetic medication in pancreatic cancer patients
Presenter: Alexander Friedrich
Session: Poster session 22
1667P - Clinical and molecular features of young onset pancreatic adenocarcinoma
Presenter: Maxime Remond
Session: Poster session 22
1668P - Prevalence and management of pancreatic ductal adenocarcinoma (PDAC) over a decade in France: A population-based study
Presenter: Léo Mas
Session: Poster session 22
1670P - Tumoral and non-tumoral thrombosis associated with pancreatic ductal adenocarcinoma (PDAC): Survival impact, assessment of predictive scales and rethrombosis
Presenter: Alejandra Cardozo
Session: Poster session 22
1671P - Treatment patterns and efficacy in patients (pt) with pancreatic cancer (PC) from the Spanish RETUD registry
Presenter: Teresa Macarulla
Session: Poster session 22
1673P - Trajectories of immune-related serum proteins and quality of life in patients with pancreatic and other periampullary cancer: The champ study
Presenter: Sofie Olsson Hau
Session: Poster session 22
1674P - VILP registry of patients with metastatic pancreatic cancer treated with pegylated liposomal irinotecan plus 5-fluoroucil and leucovorin in the Czech Republic
Presenter: Stanislav Batko
Session: Poster session 22
1675P - Diagnostic performance of blood-based DNA methylation assay using epigenetic-specific peptide nucleic acid in pancreatic adenocarcinoma
Presenter: Hongsik Kim
Session: Poster session 22
1676P - Clinical outcomes of first-line chemotherapy in locally advanced and metastatic pancreatic adenocarcinoma patients: Real-world experience
Presenter: Nunticha Umpawan
Session: Poster session 22