Abstract 2089P
Background
Febrile neutropenia (FN) resulting from myelosuppressive chemotherapy drugs, have the potential to necessitate dose reduction or treatment delays, thus compromising the overall efficacy of treatment. This study aims to analyze the incidence of FN and related adverse drug reactions in cancer patients who receive prophylaxis with PEG-rhG-CSF (a long-acting granulocyte colony-stimulating factor).
Methods
This real-world study was conducted as a multicenter, retrospective, observational research involving adult cancer patients who received chemotherapy with PEG-rhG-CSF prophylactic. The study focused on several variables, including baseline characteristics and incidence of FN. Descriptive analysis was performed by using IBM SPSS Statistics 27.
Results
24,199 patients were enrolled from 575 hospitals across China between June 2022 and January 2023. The chemotherapy cycle records encompassed 1to 20 cycle. Among the enrolled patients, breast cancer was the most prevalent tumor type, accounting for 33.6% (N=8,131) of the cases. FN incidence across all cycles was 0.054% and it was 0.055% and 0.053% among patients receiving PEG-rhG-CSF as primary and secondary prophylaxis. These rates were significantly lower than the previously reported data of 13% to 21% from a retrospective cohort study involving patients with or without prophylaxis. Overall, FN occurred across the first to eighth cycles with the highest incidence observed in cycle 1 (52.50%). 1,659 records (2.25%) reported adverse events related to PEG-rhG-CSF. The most commonly observed adverse effect was musculoskeletal pain, accounting for 1.53% of the cases, followed by fatigue(0.60%) and allergic reactions(0.07%). Furthermore, 90.78% of adverse reactions were categorized as primary or secondary adverse reactions.
Conclusions
Under PEG-rhG-CSF prophylaxis, cancer patients exhibited a low incidence of FN which primarily occurred in the initial cycle of chemotherapy. Importantly, the administration of PEG-rhG-CSF was well tolerated.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The author.
Funding
Has not received any funding.
Disclosure
The author has declared no conflicts of interest.
Resources from the same session
2106P - Safety and patient reported outcomes of SARS-CoV-2 vaccination in patients with cancer
Presenter: Amy Body
Session: Poster session 06
2107P - Thromboprophylaxis with intermediate or prophylactic doses of LMWHs in ambulatory cancer patients
Presenter: Nikolaos Tsoukalas
Session: Poster session 06
2108P - Vitamin B12 and its clinical relevance in hospitalized cancer patients
Presenter: Stefano Maccarone
Session: Poster session 06
2109P - Vitamin A, D and E levels in patients with solid tumors undergoing palliative systemic cancer treatment
Presenter: Julia Berger
Session: Poster session 06
2111P - The value of multiple psychometric tools for distress screening and referral in a cancer population
Presenter: Daniel Anderson
Session: Poster session 06
2112P - Initial geriatric assessment and chemotherapy tolerability treatment in Brazilian patients with malignant neoplasm of the digestive system
Presenter: Marcos Dumont Bonfin Santos
Session: Poster session 06
2113P - Efficacy and effectiveness of prophylactic magnesium supplementation on prevention of cisplatin-induced nephrotoxicity: A systematic review and meta-analysis
Presenter: Caio Castro
Session: Poster session 06
2114P - Impact of comprehensive geriatric assessment (CGA) in the management of chemotherapy toxicity in older cancer patients
Presenter: Jordi Recuero-Borau
Session: Poster session 06
2115P - Pre-cachexia incidence in patients with solid cancer: A cross-sectional study
Presenter: Lynn Gottmann
Session: Poster session 06