Abstract 1178P
Background
Melanoma is the fifth most common cancer and, although rare, is the most common skin malignancy in those under 20 years old in the United States (US), with an average annual incidence rate (IR) of 5.5-6.0 cases per million. Since the 1970s, the incidence of pediatric melanoma has increased with an average annual percent change of 2–2.9% in the US. Epidemiological knowledge and predictors of melanoma among children and adolescents (age < 20 years) in Korea are limited.
Methods
Using data from National Health Insurance (NHI) database, we identified incident melanoma cases diagnosed at 0-19 years old during 2004-2019 in Korea, respectively. Using a joinpoint regression model, associations between demographic factors and melanoma incidence rates (IR) were evaluated by calculating incidence rate ratios and 95% confidence intervals (CI).
Results
We identified a total of 1160 patients (age < 20 years) with cutaneous malignant melanoma from 2004-2019. The overall average annual melanoma incidence was 0.22 per million (95% CI, 0.21-0.23) in Korea. It increased with age (age 0-4: 0.3, age 5-9: 0.6, age 10-14: 0.6, age 15-19: 07 per 100,000 persons) but there was no difference in IR according to sex. The age-adjusted incidence of melanoma decreased 4.5% yearly from 2004 to 2012 (95% CI, -8.9%–0.1%) but increased 12.6% yearly from 2012 to 2019 (95% CI, 5.9%–19.6%). A strong correlation between melanoma IR and nevi was confirmed (OR 85.4, 95% CI 67.97 - 106.40, P < 0.001) and this was also linked to the survival rate (5-year survival rate: 97.7% vs 91.9%, P = 0.044).
Conclusions
Although the incidence of melanoma in children and adolescent is very low, it is clear that it increases in Korea. To our knowledge, this is the first report to suggest that melanoma IR trends in children and adolescent are annually increasing in Korea. Most importantly, we must increase awareness and education amongst pediatricians, internists and the general population with regard to prevention and early diagnosis of melanoma for both children and adults. In addition, the physicians should include a complete skin examination for children with congenital nevi.
Clinical trial identification
none
Editorial acknowledgement
none
Legal entity responsible for the study
Jisu Oh.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
1100P - Open-label non-randomized phase IB study to characterize the safety, tolerability and recommended dose of tinostamustin in combination with nivolumab in patients with advanced melanoma (ENIGMA)
Presenter: Markus Joerger
Session: Poster session 13
1101P - The effect of LNS8801 in combination with pembrolizumab in patients with treatment-refractory cutaneous melanoma
Presenter: Jordi Rodon
Session: Poster session 13
1102P - Evaluation of surrogate endpoints for overall survival within the RELATIVITY-047 trial
Presenter: Peter Mohr
Session: Poster session 13
1103P - Nivolumab (NIVO) plus relatlimab (RELA) vs NIVO in previously untreated metastatic or unresectable melanoma: 2-year subgroup analyses from RELATIVITY-047
Presenter: Georgina Long
Session: Poster session 13
1104P - Efficacy of immune checkpoint inhibition in metastatic or non-resectable melanoma after failure of adjuvant anti-PD1 treatment: A EUMelareg real-world evidence study
Presenter: Michael Weichenthal
Session: Poster session 13
1105P - First-line nivolumab plus ipilimumab in advanced melanoma patients previously treated with adjuvant systemic therapy
Presenter: Katarzyna Kozak
Session: Poster session 13
1106P - Anti-PD-1 (PD1) monotherapy or in combination with anti-CTLA-4 for metastatic melanoma (MM) patients (pts) with liver metastases (mets)
Presenter: Ines Pires da Silva
Session: Poster session 13
1107P - BRAF mutation status does not impact outcomes with tebentafusp in advanced cutaneous melanoma
Presenter: Alexander Shoushtari
Session: Poster session 13
1108P - Outcomes of patients with unresectable or metastatic melanoma after cessation of immunotherapy following complete response or toxicities
Presenter: Nur Sakinah Zulkifli
Session: Poster session 13