1579P - Gender differences and worse metastatic survival outcomes in young adult patients with oesophagogastric cancer: 12-year data from a Czech comprehensive cancer center

Background

The US Surveillance, Epidemiology, and End Result (SEER) data indicated an increasing incidence of early-onset GI tract cancers. According to published data, the treatment outcomes of young adults (YA) are comparable to the general population. We aimed to analyze the clinicopathological characteristics and overall survival (OS) of YA treated in a comprehensive cancer center.

Methods

Patients diagnosed with oesophagal (OC), oesophagogastric junction (OGJ), or gastric (GC) cancer between 2010 and 2022 were retrospectively identified from the Masaryk Memorial Cancer Institute database. Inclusion criteria were 1) age 18-50 years, 2) histology, and 3) treatment according to international recommendations.

Results

The consecutive patient cohort included 1725 patients, of which 162 met the inclusion criteria, representing approximately 10% of YA patients from the Czech Republic. In 63% of cases, the patients were men, significantly older than women (84% vs 65% in the age group 40-49 years, p=0.005). In women, tumors were more often located in the stomach (78% vs 53%, p=0.001) and primary metastatic (67% vs 50%, p=0.039). Six patients had localized disease (stage I), 36 (16 OC/OGJ, 20 GC) underwent radical resection, 31 (15 OC/OGJ, 16 GC) were unresectable, and 86 metastatic (25 OC/OGJ, 61 GC). With a median follow-up of 67 months, 131 (81%) deaths were recorded. Radically resected patients achieved a median OS of 54 mo with a 5-year OS of 42%, whereas the median OS for the unresectable and metastatic disease was 11 mo, and 8.6 mo, respectively.

Conclusions

In our YA cohort, men were older, while women were more likely to have metastatic gastric cancer. OS for the locally advanced disease was comparable to published studies observing the general population but noticeably shorter for metastatic disease.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

The authors.

Funding

Has not received any funding.

Disclosure

All authors have declared no conflicts of interest.