ESMO Congress 2023 | OncologyPRO

Abstract 1570P

Background

Patients with Esophageal Cancer (EC) have variable responses to (chemo)radiotherapy. A reliable early prediction of outcomes allows for enhancing treatment efficacy and follow-up monitoring. DCE-MRI can provide information regarding tumor perfusion and permeability and has shown prognostic value in certain tumor types. Our aim was to investigate the potential application of DCE-MRI parameters as predictors for progression-free (PFS) and overall survival (OS) inpatients with EC treated with concurrent chemoradiation (CRT).

Methods

This study involved fifty-two patients with esophageal cancer and treated with CRT. The patients underwent DCE-MRI before CRT (pre-CRT) in three weeks and three weeks after starting CRT (post-CRT). Patients were grouped into high and low risk groups according to the cut-off value of best OS and PFS respectively. The correlations between quantitative parameters of DCE-MRI (pre-K^trans, post-K^trans and the changes and ratios of parameters (ΔiK^trans, riK^trans), and OS/PFS were calculated and compared between two-time frames in two groups, respectively. The K-M method was used to calculate the survival curve, and the log-rank method was used to compare differences in the survival curves.

Results

The level of pre-CRT K^trans was positively associated with OS (cutoff value=70.53/min, p=0.113) and PFS (cutoff value=70.53/min, p=0.026). The level of post-CRT K^trans was impaired associated with OS (cutoff value=45.60/min, p=0.001) and PFS (cutoff value=45.60/min, p=0.003). Level of riK^trans was impaired associated with OS (cutoff value=0.374, p=0.024) and PFS (cutoff value=0.374, p=0.040). The level of ΔiK^trans was impaired associated with OS (cutoff value=4.5/min, p=0.048) and PFS (cutoff value=0.595/min, p=0.056).