Abstract 984P
Background
Several scoring systems have been proposed to predict the outcome of transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC). However, the application of the albumin-bilirubin (ALBI) grades to TACE candidates is poorly validated. Evaluation of the applicability of prognostic factors for patients performing TACE is necessary. We aimed to develop new scoring system including ALBI grade.
Methods
2,632 patients with unresectable HCC, child class A/B and ECOG 0-1 performing TACE were included from national cohort of the Korean Central Cancer Registry between 2008 to 2017. Patients were randomly divided into training (n=1,304) and validation cohort (n=1,328). A prognostic model was developed and validated. We compared with previous scoring models.
Results
In entire cohort, the patient’s mean age was 63 years. The patients were hepatitis B virus (57.1%) and child class A (83.2%). The prognostic model of TACE was ‘‘largest tumor diameter+ tumor number, AFP, and ALBI grade”, which consistently outperformed other currently available models in both training and validation datasets. Patients were assigned points according to sum of tumor burden (≤5, 5-10, ≥10), AFP or ALBI grade. Patients were divided into four risk groups based on their TACE-prognostic (TP) scores: A, B, C and D. The median survival for the groups A, B, C and D was 85.9, 67.3, 52.8 and 33.0 months, respectively.
Conclusions
This new TP scoring system may prove a favorable tool to stratify ideal candidates of TACE and predict OS with favorable performance and discrimination. Further external validation is needed.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.
Resources from the same session
978P - Post-progression outcomes of advanced HCC patients (aHCC pts) treated with first-line atezolizumab/bevacizumab (A/B)
Presenter: Claudia Fulgenzi
Session: Poster session 18
979P - Safety interim analyses of first-line systemic therapy with atezolizumab plus bevacizumab (ATZ+BEV) in patients from Spain with unresectable hepatocellular carcinoma (HCC): Phase IIIb ATHECA
Presenter: Maria Elisa Reig Monzon
Session: Poster session 18
980P - Neutrophil count predicts the complete response after transarterial chemoembolization related to favorable outcome in hepatocellular carcinoma
Presenter: Young Mi Hong
Session: Poster session 18
981P - The response of portal vein tumoral thrombosis to moderately hypo-fractionated radiotherapy using intensity modulated radiotherapy
Presenter: Ahmad Abdel-Azeez
Session: Poster session 18
982P - Transarterial chemoembolization with idarubicin versus epirubicin for hepatocellular carcinoma: An interim analysis of a multicentre, randomized controlled phase III trial
Presenter: Zhewei Zhang
Session: Poster session 18
983P - Safety and efficacy of durvalumab plus hepatic artery infusion chemotherapy in HCC with severe portal vein tumor thrombosis (Vp3/4) – the DurHope study
Presenter: Ming Zhao
Session: Poster session 18
987P - Safety and efficacy of lenvatinib in patients with unresectable hepatocellular carcinoma (uHCC) in real-world practice in Korea
Presenter: Wonseok Kang
Session: Poster session 18
988P - Burden of primary liver cancer in the Middle East and North Africa Region from 1990 to 2019
Presenter: Ahmed Hafez Allam
Session: Poster session 18