Abstract CN85
Background
Severe radiation dermatitis can negatively show some symptoms for the patient and may lead to the interruption of radiotherapy. Several interventions for the management of radiation dermatitis have been described in the literature, but there is no standardized intervention. This study compared a chamomile liposomal gel and a liposomal gel to prevent of severe radiation dermatitis in breast cancer patients undergoing radiotherapy.
Methods
This study was a double-blind randomized clinical trial. One hundred participants undergoing radiotherapy for breast cancer were recruited. The participants received hypofractionated or conventional fractionation radiotherapy at the University Hospital of Brasilia, Brazil. The skin of participants was evaluated daily and registered the first occurrence of moist desquamation and cumulative dose of ionizing radiation at the first occurrence of moist desquamation. In addition, participant's self-reported symptoms and skin hydration were evaluated weekly.
Results
The chamomile liposomal gel group had a lower proportion of moist desquamation and more delay in the mean cumulative dose of the first occurrence of moist desquamation (6.0% vs. 8.2% respectively [p=0.72]; 46.3 Grays (Gy) vs. 43.4 Gy respectively [p=0.42]) compared to the liposomal gel group but were no statistical differences. There was a lower proportion of self-reported symptoms in the chamomile liposomal gel group compared to the liposomal gel group. Throughout the weekly evaluations, in the supraclavicular and frontal regions of the breast, skin hydration was higher in the chamomile liposomal gel group compared to the liposomal gel group.
Conclusions
The chamomile liposomal gel showed a better effect in the prevention of severe radiation dermatitis compared to liposomal gel in breast cancer patients undergoing radiotherapy. No statistically significant differences were found, but the two gels showed benefits in use and are potential interventions to be used in the management of signs and symptoms of radiation dermatitis.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Interdisciplinary Laboratory of Research applied to Clinical Practice in Oncology, Faculty of Health Sciences, University of Brasília, Brasília, Brazil.
Funding
Coordination for the Improvement of Higher Education Personnel (CAPES) and National Council for Scientific and Technological Development (CNPq), Brazil.
Disclosure
All authors have declared no conflicts of interest.