Abstract 875P
Background
Among Italian people under 50 years of age, cutaneous melanoma (CM) represents the third most common incident cancer in women. This study aims to describe trends in CM incidence among women residing in Friuli Venezia Giulia region (FVG), North-East Italy from 2000 to 2020.
Methods
A descriptive study was conducted using de-identified data from the population-based regional Cancer Registry. To describe CM incidence among women residing in FVG from 2000 to 2020, descriptive statistics and age-standardized incidence rates (ASR) were estimated according to calendar period, age at diagnosis, histology, cancer site and stage. To assess temporal trends, annual percent change (APC) in rates, and 95% confidence intervals (CI), were computed using Joinpoint regression analysis.
Results
etween 2000 and 2020, 3292 CM cancer cases were newly diagnosed among women residing in FVG. ASR were stable until 2013 (APC=1.4, IC95%: -0.2 to 3.1), they increased from 2013 to 2018 (APC= 13.5%, IC95%: 4.7 to 22.9), and they thereafter slightly decreased (not significantly) until 2020 (APC=-13.1, IC95%: -31.2%-+9.7%). Increased ASR (/105 per year) were documented for all age classes: from da 10.5 to 18.0 cases for women aged < 50; from 23.3 to 49.3 cases for those aged 50-69; and from 33.2 to 54.4 cases for those aged 70+. The trunk turned out to be the anatomic site with the highest increase in incidence rates, from 4.4 cases/105 per year in 2000-2004 to 11,4 cases/105 per year in 2015-2019. The proportion of CM diagnosed in advanced stage (Breslow thickness > 4mm) decreased from 13,6% in 2008 to 4,7% in 2020.
Conclusions
CM incidence increased among women of all ages living in FVG,from 2000 to 2018, with a slight decrease in 2019-2020. These results support the importance of enhancing primary and secondary prevention programs among FVG women.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.