Abstract 326P
Background
Vitamin D has a role in carcinogenesis and may have effect on recurrence.
Methods
Patients’ vitamin D values were assessed under 4 groups according to baseline and follow up vitamin D values, and whether vitamin D supplementation use. First relationship between baseline/follow-up vitamin D levels and DFS/OS were analyzed, then, the effect of vitamin D supplementation and follow-up level on DFS and OS were analyzed in patients operated curative intent stage I-IV colorectal-cancer (CRC).
Results
A total of 243 CRC patients were included in this retrospective study. The median vitamin D level of 48.6% of the patients was below 15ng/mL. Gender, age, diagnosis (colon/rectum), tumor location, patients’ comorbities did not affect DFS, wheares initial vitamin D level had impact on DFS as trend toward and stage had a strong effect on DFS. Follow-up vitamin D level predicted DFS with statistically significance in univariate and multivariate analysis when adjusted for gender and stage (HR;95%CI:2.732;1.612-4.632;p<0.001). In addition, patients with high follow-up vitamin D level and high vitamin D level after supplementation presented similar hazard ratio for DFS (HR;95%CI:1.89;0.698-5.108;p=0.211), while patients with low follow-up vitamin D level and low vitamin D level after supplementation presented with worse DFS (HR;95%CI:4.83;2.086-11.19;p<0.001, HR:95%CI:5.03;1.985-12.77,p=0.001, respectively) compared to patients with high vitamin D value. When the patients evaluated according to vitamin D supplementation status; accordingly, patients with high follow-up vitamin D level and high vitamin D level after supplementation presented similar hazard ratio for OS (HR; 95%CI: 1.35; 0.531-3.444; p=0.525), while patients with low follow-up vitamin D level and low vitamin D level after supplementation presented with worse OS (HR; 95%CI: 2.79; 1.289-6.057, p= 0.009;HR:95%CI:2.82;1.169-6.779,p=0.021, respectively) after adjusted for stage, age, and gender compared to patients with high vitamin D level.
Conclusions
Follow up vitamin D values seems to be a good predictive biomarker and vitamin D replacement may have a positive effect on recurrence and survival in colorectal cancer patients.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.