Abstract 641P
Background
Frailty is an important marker of poor outcomes in older adults with hematological malignancy and leads to significant vulnerability to adverse health outcomes of the elderly population. This study aimed to identify the association between frailty and outcomes in hospitalized patients with chronic myeloid leukemia (CML).
Methods
A population-based, retrospective study.Data of hospitalized patients aged 20 years or older diagnosed with CML between 2016 and 2018 were identified in the US Nationwide Inpatient Sample (NIS) database through the International Classification of Diseases (ICD-10). The cohort was further categorized into a patient group with or without frailty. Logistic regression analyses were performed to determine the associations between study variables and clinical outcomes. Stratified analyses on the association between frailty and in-hospital mortality by different age groups were also performed.
Results
A total of 13,849 hospitalized CML patients were included, containing 49.6% with identified frailty. Patients’ mean age was 65.1 years, and 7,619 (56.2%) were males. Frailty was independently associated with nearly the risk of 4 times in-hospital mortality, 3 times unfavorable discharge, 3 times prolonged LOS, 6 times sepsis, 2.5 times pneumonia, and an additional 32 thousand USD in total hospital cost. Furthermore, when stratified by age categories, frailty posed an approximately 3-time risk for in-hospital death among patients <40 years and >60 years, whereas a 6-time risk was observed among patients 40-59 years old.
Conclusions
Frailty is a strong predictor for adverse clinical outcomes in CML patients in the US. It significantly affects in-hospital mortality among patients of 40-59 years old than their older counterparts.
Clinical trial identification
Editorial acknowledgement
This study was supported by grants from Taipei Medical University Hospital (108TMU-TMUH-24).
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.