Abstract 1166P
Background
In England more deprived groups are more likely to acquire lung cancer and have a higher associated mortality despite adjusting for disease stage at diagnosis and comorbidities [1]. More deprived populations are more frequently exposed to risk factors for disease development such as smoking and air pollution [2]. St Bartholomew’s Hospital serves a diverse population from East London. We aim to understand if there are associations between clinico-pathological features of lung cancer and levels of deprivation in our region.
Methods
Electronic patient records were reviewed for patients diagnosed with lung adenocarcinoma at our centre over 1 year between January and December 2021. Deprivation deciles were obtained via the English Indices for Deprivation 2019 [3].
Results
170 patients were identified, of which 75.3% (n=128) had an oncogenic driver mutation. Median age was 69 years with 45.3% females (n=77). The most frequently identified mutation was KRAS (n=62, 36%), followed by EGFR (n=18, 10.6%). 6.5% of patients (n=11) had 2 or more mutations. EGFR was associated with higher deprivation in the living environment subdomain (p=0.046), measuring exposure to poor quality air and housing, road traffic accidents and access to central heating. No other significant relationships between deprivation score and tumour mutational status were identified.
Conclusions
Lung cancer patients at our centre are distributed along a deprivation gradient, comparable to the local population makeup. Considering EGFR’s association with never-smoking populations, these findings are consistent with the hypothesis that these populations are also exposed to important oncogenic factors beyond smoking tobacco [2] and that a drive to reduce the burden of cancer must not be limited to smoking cessation alone. References [1] NCRAS, “Cancer by Deprivation in England 1996 - 2011,” 2014. [2] H. A. Powell, “Socioeconomic deprivation and inequalities in lung cancer: time to delve deeper?,” Thorax, vol. 74, no. 1. England, pp. 11–12, Jan-2019. [3] “National Statistics English Indices of Deprivation,” 2019. [Online]. Available: https://www.gov.uk/government/statistics/english-indices-of-deprivation-2019. [Accessed: 24-Mar-2022].
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.