Abstract 1566P
Background
Poor sleep quality and depression in cancer patients are common problems during receiving systemic therapy, however these problems were usually been neglected which can lead to poor quality of life. Association between sleep quality and depression need to be explored for improving quality of life and outcome of cancer therapy.
Methods
A prospective, cross-sectional study in cancer patients receiving first-line and cycle of chemotherapy at day 0 and 28 days after treatment. Two validated questionnaires were used in this study, Pittsburgh Sleep Quality Index (PSQI) scale was used to assess sleep quality together with Patient Health Questionnaire (PHQ)-9 was used to screen depression. Multivariate logistic regression analysis was used to find association factors.
Results
A total 92 eligible cancer patients were included. Of these, 65.22% (N=60) had Global PSQI ≥ 5 which indicated poor sleep quality. Regarding to PSQI scale before and after 28 days of treatment, Mean Global PSQI increased from 3.52 (± 2.56) to 6.97 (± 4.00), p-value < 0.01. Apart from PSQI scoring, Mean PHQ-9 depression score also increased from 2.59 (±3.58) to 6.33 (± 5.31), p-value <0.01. Multivariate analysis revealed significantly related factors as disease concerning odd ratio 5.96 (95%CI 2.07-17.11) and medication and administration with odd ratio 13.89 (95%CI 1.70-113.53). Moreover, from The Pearson’s correlation coefficient showed a positive correlation between depression scores and sleep quality scores after chemotherapy, r = 0.74 (P <0.01, 95%CI: 0.63 – 0.82). Table: 1566P
Comparison of mean (± standard deviation) scores on global PSQI, PSQI subscales and PHQ-9 after chemotherapy
| Score | Mean (± standard deviation) before chemotherapy | Mean (± standard deviation) after chemotherapy | P-value |
| Global PSQI (Range 0-27) | 3.52 (± 2.56) | 6.97 (± 4.00) | < 0.01 |
| Subscale (Range 0-3) | |||
| Subjective sleep quality | 0.59 (± 0.76) | 1.36 (± 1.03) | < 0.01 |
| Sleep latency | 1.15 (± 0.69 | 1.65 (± 0.84) | < 0.01 |
| Sleep duration | 0.62 (± 0.55) | 0.77 (± 0.59) | 0.01 |
| Habitual sleep efficiency | 0.16 (± 0.50) | 0.30 (± 0.64) | 0.08 |
| Sleep disturbance | 0.65 (± 0.58) | 1.00 (± 0.47) | < 0.01 |
| Use of sleep medication | 0.13 (± 0.50) | 1.33 (± 1.21) | < 0.01 |
| Daytime dysfunction | 0.22 (± 0.46) | 0.55 (± 0.69) | < 0.01 |
| PHQ-9 | 2.59 (± 3.58) | 6.33 (± 5.31) | < 0.01 |
Conclusions
Poor sleep quality and depression had increased after receiving chemotherapy which related to many significant factors. Besides, sleep quality also had positive correlation with depression score as well. Therefore, early detection and prevention of these problems may lead to improve quality of life.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Faculty of Medicine, Srinakharinwirot University.
Disclosure
All authors have declared no conflicts of interest.