Abstract 1505P
Background
Synovial sarcoma is a rare soft tissue neoplasm that usually occurs in the arms and legs, but it can occur in all parts of the body and across all ages. There are differences in management and outcomes for patients who have localized disease compared with distant spread at the time of diagnosis. The purpose of this study was to examine potential risk factors predictive of metastatic disease at presentation.
Methods
The Surveillance, Epidemiology, and End Results (SEER) Program database was used to identify all patients diagnosed with synovial sarcoma from 2000 to 2018 and to classify each patient as having metastatic or localized disease at the time of diagnosis. Patient-based characteristics, tumor characteristics, and socioeconomic measures were analyzed to determine which factors were predictive of an increased rate of metastatic disease at presentation. These factors were analyzed using univariate as well as a multivariate logistic regression model.
Results
We identified 2,162 cases of histologically confirmed synovial sarcoma, and 382 (17.7%) of the patients presented with metastatic disease. Based on the unadjusted logistic regression analysis, patients had the highest odds of metastatic disease at presentation if they had an age of more than fifty years (odds ratio [OR] = 2.77; 95% confidence interval [CI], 2.00 to 3.80), had a tumor located in the pelvic area (OR = 3.28; 95% CI, 2.13 to 5.06), and had a tumor size greater than 10 cm (OR = 8.98; 95% CI, 5.87 to 13.74). These factors remained significant when combined in a multivariate model controlling for age, sex, race, tumor location, histology, size, and socioeconomic factors. For patients with recorded tumor size information (n = 1,531), the odds of metastasis at presentation increased by 6.0% with each additional centimeter of tumor size (OR = 1.06; 95% CI, 1.04 to 1.09). However, this relationship lost significance in the multivariate model.
Conclusions
Synovial sarcoma patients with age greater than fifty years, a tumor in the pelvic area, and a large tumor size, were more likely to have metastatic disease at presentation. Identifying patients with such characteristics may guide early metastatic workup and clinical management.
Clinical trial identification
N/A
Editorial acknowledgement
N/A
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.