Abstract 607P
Background
To assess the impact of omentectomy on the prognosis and fertility outcomes of patients with clinically apparent early-stage (I, II) malignant ovarian germ cell tumors (MOGCT).
Methods
In this retrospective cohort analysis, 268 patients with clinically apparent early-stage (I, II) MOGCT between 2005 to 2020 from major university-teaching hospitals in China were identified. A 1:1 propensity score matching (PSM) between omentectomy and no-omentectomy groups was performed and disease-free survival (DFS), overall survival (OS) and reproductive outcomes were compared between groups.
Results
A total of 268 patients with clinically apparent early-stage MOGCT were included. And 187 (69.8%) patients underwent omentectomy, among whom 3 (1.6%) had omental metastasis. Kaplan-Meier analysis showed no significant differences in DFS and OS between omentectomy and no-omentectomy groups in the before and after PSM cohorts (p>0.05). Additionally, the subgroup analysis stratified by age <18 or ≥18 years, showed the similar results. Cox regression analysis revealed that the FIGO stage was the only risk factor associated with DFS (HR=14.71, CI 4.47-48.38, p<0.001) and OS (HR=37.36, CI 3.87-361.16, p=0.002). Regarding the fertility outcomes, the pregnancy rates and live birth rates of the total population were 80.3% and 66.7%, respectively. And there were no significant differences between the two groups in the before and after PSM cohorts.
Conclusions
Omentectomy did not seem to improve survival for either children/adolescent or adult patients with clinically apparent early-stage (I, II) MOGCT and had no impact on fertility outcomes. The FIGO stage was the independent risk factor associated with recurrence and death.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
This study was supported by the National Key Technology Research and Development Program of China (2019YFC1005200 and 2019YFC1005204), the Taishan Scholar Youth Project of Shandong Province (tsqn201812130), and the Research Leader Studio of Jinan (2019GXRC049).
Disclosure
All authors have declared no conflicts of interest.