Abstract 395P
Background
Bowel cancer (BC) or colorectal cancer (CRC) is one of the most common forms of cancer accounting for 10% of global cancer incidence. In the UK, the incidence appears to be 11%. Prevention remains a key facet to improve prevalence rates of Bowel Cancer, coupled with screening and treatment. The potential bidirectionality of those with a pre-existing mental illness who are diagnosed with BC versus those who report mental health (MH) symptoms following a BC diagnosis that may or may not require a comprehensive MH diagnosis globally remains unclear. The current study explores this to better manage the prognosis, morbidity, and mortality of these BC patients. However, secondary problems related to physical and mental health conditions are common among cancer patients. for BC.
Methods
A case-controlled epidemiology study using a retrospective, real-world data processed through the AKrivia Health platform using the United Kingdom Clinical Record Interactive Search (UK-CRIS) system anonymized dataset. All data within the UK-CRIS database is de-identified. We have used a prevalence analysis model including relative survival. All participant data included had a diagnosis of BC and clinical depression.
Results
Preliminary results from a dataset of 8689 patients, consisting of 56.63% men and 46.37% women, identified 706 (8.13%) patients with bowel cancer. Pearson's chi-square test showed an association between the neuropsychiatric and the BC diagnosis in both. For both genders, schizophrenia was more prevalent among those diagnosed with BC than would be expected if there was no association between diagnoses. The diagnosis of bipolar disorder was less prevalent than expected with 6.27% (49) in comparison to 10.20% (151) diagnosed with schizophrenia, and 8.09% (194) diagnosed with some type of psychosis in the male group. Interestingly the female group, reported 10.18% (79) diagnosed with schizophrenia, 7.90% (149) with psychosis, and 6.15% (84) with bipolar.
Conclusions
Our results show that schizophrenia and psychosis are the most prevalent among men. These results are vital for better prognostic management of patients. In addition, they are fundamental to understanding the intimate relationship between mental health and bowel cancer.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
Gayathri Delanerolle.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.