Abstract CN87
Background
Cancer related cognitive impairment (CRCI) is a common and persistent symptom in breast cancer patients. The Attentional Function Index (AFI) is a self-report measure that assesses CRCI. AFI includes three subscales, namely effective action, attentional lapses, and interpersonal effectiveness, that are based on working memory, inhibitory control, and cognitive flexibility. Previously, we identified three classes of patients with distinct CRCI profiles using the AFI total scores. The purpose of this study was to expand our previous work, and to identify distinct cognitive profiles for each of the AFI subscales in the same sample (i.e., 397 women who were assessed seven times from prior to through 6 months following breast cancer surgery).
Methods
Latent class growth analysis (LCGA) was conducted to identify the numbers of the three subscales. For each subscale, parametric and non-parametric statistics were used to determine differences in demographic, clinical, and presurgical psychological and physical symptoms among the subgroups.
Results
Three-, four-, and two-classes were identified for the effective action, attentional lapses, and interpersonal effectiveness subscales, respectively. Across all three subscales, lower functional status, higher levels of anxiety, depression, fatigue, and sleep disturbance, and worse decrements in energy were associated with worse cognitive performance.
Conclusions
Pre-surgery symptoms and other modifiable characteristics associated with the worst performance classes may be potential targets for personalized interventions for CRCI.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
C. Miaskowski.
Funding
National Cancer Institute (CA107091 and CA118658); European Union Horizon 2020, Marie Sklodowska-Curie Research and Innovation Award (No 801076); Swiss Cancer League (KLS-4294-08-2017).
Disclosure
All authors have declared no conflicts of interest.