Abstract 1568P
Background
Assessment of physical condition (PC) is of utmost interest for physicians and specifically for medical oncologists, since it is highly informative for the process of therapeutic decision-making. PC is the ability to carry out daily tasks with vigour and alertness, without undue fatigue and with ample energy to engage in leisure time pursuits and to meet the above-average physical stresses encountered in emergency situations. The concept of PC includes different components: (a) body composition, (b) cardiorespiratory component, (c) muscular component (muscular strength and muscular endurance), and (d) motor component (balance, flexibility, speed).
Methods
To identify differences in the PC of patients (pts) with localized and metastatic diseases at the time of diagnosis. Pts with a recent diagnosis of colorectal cancer (CRC) who were able to walk a mile were evaluated at the hospital setting. Body composition was evaluated through BMI, cardiorespiratory component through the Rockport test which estimates VO2max with Kline formule, (c) muscular component through dynamometry (hand-grip) and “sit to stand” test and (d) walking speed through both one-mile walk test (OMWT) and six-minute walk test (SMWT).
Results
188 pts were recruited. Mean age 65 (25-88), 188 (125 male/63 female) patients were included. 111 stage II-III/ 77 stage IV. Table: 1568P
| BMI | Basal heart rate | Rockport test | Walking speed | Muscular strength | |||
| (kg/m2) | (beats per minute) | VO2max (ml/kg/min) | Time to walk one mile (min) | Distance in 6 minutes (meters) | Upper body Dyn (Kg) | Lower body STS (seg) | |
| Total | 26.8 | 76.1 | 24.2 | 17.2 | 557 | 32.0 | 7,8 |
| Localized | 26.7 | 74.9 | 26.2 | 16.7 | 545 | 32.2 | 7,9 |
| Metastatic | 27.0 | 78.2 | 20.8 | 18.0 | 564 | 31.8 | 7.7 |
| p-value | ns | 0.047 | 0.00 | 0.008 | ns | ns | ns |
Conclusions
Objective evaluation of PC is feasible at the hospital setting. PC is different in metastatic and localized disease at the time of diagnosis but does not affect equally all the components of PC. Whereas cardiorespiratory component is much poorer in metastatic patients, muscular strength and BMI are similar in both groups. SMW test could be insufficient for stratifying population without respiratory disease or lung cancer. Rockport test or OMWT is feasible and sensitive and could be used as an additional tool to select patients for aggressive therapies.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
M. Romero-Elias: Financial Interests, Personal, Advisory Board: Sanofi. A. Ruiz-Casado: Financial Interests, Personal, Invited Speaker: Servier, Viatris, Abbott; Financial Interests, Personal, Advisory Board: Sanofi, Bayer. All other authors have declared no conflicts of interest.