Abstract 1152P
Background
Metastatic disease at the time of lung cancer diagnosis portends poor outcomes. Differences in metastasis among Caucasians (C) and African-Americans (AA) need elucidation. We analyzed metastasis patterns in C and AA in small cell lung cancer (SCLC), squamous cell lung cancer (SQC), lung adenocarcinoma (LA), and large cell lung cancer (LCC).
Methods
We identified SCLC, SQC, LA, and LCC patients from the Surveillance, Epidemiology, and End Results Program (SEER) database 2010-2018. We obtained metastasis data to bone, brain, and liver at the time of diagnosis. We calculated the relative risk (RR), confidence interval (CI), and standard error using SPSS software, version 28.0 (IBM). P values <0.001 considered significant (S), otherwise non-significant (NS).
Results
The risk of brain metastasis (BM) is higher in AA in all subtypes but LA. BM was highest in SCLC and LCC 14-16%. AA had less liver metastasis in SCLC and LCC but higher in SQC and LA. C had higher bone metastasis in SCLC. Organ with most metastasis was identical in AA and CC; liver in SCLC and LA, and bone in SQC and LCC. Otherwise, there was no difference in metastasis to the brain in LA and metastasis to the bone in LCC (significant results are summarized in the table). Table: 1152P
| Total | AA versus C, Metastasis site prevalence (%). RR, 95% CI, p-value | |
| SCLC | AA 5161 C 49608 | Bone AA (19.1%) C (22.2%) - RR 0.87 - CI [0.81 to 0.93] S Brain AA (16.5%) C (14.3%) - RR 1.13 - CI [1.05 to 1.21] S Liver AA (25.4%) C (30.8%) - RR 0.84 - CI [0.79 to 0.89] S |
| SQC | AA 26005 C 183497 | Bone AA (6.7%) C (5.0%) - RR 1.27 - CI [1.22 to 1.33] S Brain AA (2.7%) C 3892 (2.1%) - RR 1.22 - CI [1.14 to 1.31] S Liver AA (4.7%) C (3.3%) - RR 1.35 - CI [1.29 to 1.43] S |
| LA | AA 139960 C 799921 | Bone AA (8.3%) C (8.1%) - RR 1.04 - CI [1.02 to 1.06] S Liver AA (10.8%) C (10.4%) - RR 1.06 - CI [1.05 to 1.08] S |
| LCC | AA 4034 C 24838 | Brain AA (16.4%) C (14.0%) - RR 1.12 - CI [1.04 to 1.21] S Liver AA (9.9%) C (11.7%) - RR 0.88 - CI [0.80 to 0.97] S |
Conclusions
This study shows disparities in lung cancer subtypes metastasis amid AA and C. Studies of biological and other factors are needed.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.