Oops, you're using an old version of your browser so some of the features on this page may not be displaying properly.

MINIMAL Requirements: Google Chrome 24+Mozilla Firefox 20+Internet Explorer 11Opera 15–18Apple Safari 7SeaMonkey 2.15-2.23

Mini Oral session: Haematological malignancies

626MO - Incidence of cardiovascular disease in Swedish healthy blood stem cell donors

Date

12 Sep 2022

Session

Mini Oral session: Haematological malignancies

Topics

Clinical Research

Tumour Site

Leukaemias

Presenters

Simon Pahnke

Citation

Annals of Oncology (2022) 33 (suppl_7): S283-S294. 10.1016/annonc/annonc1055

Authors

S. Pahnke, H. Hägglund, G. Larfors

Author affiliations

  • Medical Sciences, Uppsala University, Unit of haematology, 75185 - UPPSALA/SE

Resources

Login to get immediate access to this content.

If you do not have an ESMO account, please create one for free.

Abstract 626MO

Background

The last 20 years has seen a steady increase in the use of Granulocyte Colony-Stimulating Factor (G-CSF) in healthy donors, to obtain peripheral blood stem cells for allogeneic stem cell transplantation. There has been a concern that G-CSF could potentially increase the risk of cardiovascular disease in donors after donation.

Methods

In a Swedish national cohort study, we examined the incidence of new diagnoses of cardiovascular disease after donation, and all-cause death, in 1098 peripheral blood stem cell donors (PBSC) who donated between 1998 and 2014. By linking data from three Swedish national population-based registers; the Patient Register, the Multi-Generation Register, and the Cause of Death Register, we created a database on all cardiovascular disease diagnoses for 1098 PBSC donors, their 1222 siblings, and 854 bone marrow donors, and time of death for those that had deceased. For each PBSC donor, five population-based controls, with the same year of birth, sex, and county of residence as the donor, were drawn at random from the general Swedish population, using the Total Population Register, 5495 in total. Data linkage was performed at the Swedish National Board for Health and Welfare using national identification numbers, which were removed before delivery of the datasets for statistical analyses. The study was approved by the regional ethical review boards of Stockholm, 98–259, and Uppsala, 2016–497.

Results

The cardiovascular disease incidence for PBSC donors, 18.1 cases per 1000 person-years, was not different from matched population controls, 19.2 cases per 1000 person-years, hazard ratio 0.89 (95% confidence interval (CI) 0.75 – 1.06 , p-value 0.19), bone marrow donors or non-donating siblings, after a median follow-up time of 9.2 years. Mortality from any cause was registered for 32 of 1098 PBSC donors (2.9%) during follow up, compared to 240 of 5495 population controls (4.4%), hazard ratio 0.65 (95% CI 0.45–0.94, p-value 0.02).

Conclusions

The long-term incidence of cardiovascular disease in healthy donors was not increased after peripheral blood stem cell donation with the use of G-CSF, and donor mortality after donation was lower than age-, sex and residency-matched population controls.

Clinical trial identification

Editorial acknowledgement

Legal entity responsible for the study

Uppsala University, Uppsala, Sweden.

Funding

The Nordic Cancer Union, the Swedish Cancer Society and the Uppsala-Örebro Regional Research Council.

Disclosure

All authors have declared no conflicts of interest.

This site uses cookies. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used.

For more detailed information on the cookies we use, please check our Privacy Policy.

Customise settings
  • Necessary cookies enable core functionality. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences.