Abstract 245P
Background
Current major guidelines recommend only mammography as routine imaging surveillance for asymptomatic breast cancer survivors after curative treatment. However, as improving of the treatment for patients with metastatic disease, we assume that the detection of metastases in an asymptomatic status may improve the survival. Therefore, we investigated impact of intensive imaging surveillance on survival in breast cancer patients who developed distant metastasis as a first event.
Methods
We retrospectively analyzed the medical records from two institutions. The data included metastatic breast cancer patients as a first event after curative surgery from 1999 to 2021. Patients were classified into three groups (group I, distant metastasis was detected by symptoms without any regular surveillance; group II, by symptom between routine intensive imaging surveillance; group III, by regular intensive imaging surveillance without symptoms). Propensity score matched (PSM) analysis was performed with following covariates: age, subtypes, time interval from the diagnosis to metastasis, pathologic stage. Overall survival after distant metastasis (dmOS) was defined as the period from the first date of diagnosis with distant metastasis to the date of death of any cause or to the date of last follow-up.
Results
A total of 921 patients were eligible for this study. The median follow-up period was 62 months (range 6-266months). Of these patients, group I, II, and III contained 63 (6.8%), 234 (25.4%), and 624 (67.8%) patients. The median dmOS of group I, II, and III was 23, 12, and 26 months. The dmOS of group II showed significantly worse than group I (p=0.005) and group III (p<0.001). After PMS by the ratio of 1:1:1, 63 patients were remained in each group. The median dmOS of group I, II, and III was 23, 23, and 32 months. The better dmOS of group III than group I or II was found. (group I versus group III, p<0.001; group II versus group III, p=0.001).
Conclusions
Patients whose distant metastasis was detected on routine intensive imaging surveillance in asymptomatic status have significantly better outcomes than the patients whose distant metastasis was detected by symptoms.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
Has not received any funding.
Disclosure
All authors have declared no conflicts of interest.