Abstract 177P
Background
Little is known about long-term health related quality of life (HRQoL) in older breast cancer survivors and whether prior chemotherapy or endocrine therapy impacts long-term health.
Methods
Texas Cancer Registry-Medicare linkage data were used to identify breast cancer patients age 65 and older at diagnosis with local/regional stage disease diagnosed from 1/2012 through 12/2013. Survivors completed mailed questionnaires including the Veterans RAND 12 Item Health Survey, which were completed between 4/2018 and 10/2019. Demographic and clinical data also were collected. The physical component scores (PCS) and mental component scores (MCS) were calculated to a standardized score of 0-100. The modified regression estimation (MRE) approach was used to impute missing responses. Higher scores indicate more favorable physical and mental health status, with the general US population having a mean score of 50. ANOVA and t-test with two-sided significance level of 0.05 were used to compare PCS and MCS scores across subgroups.
Results
Of 4,448 eligible patients, 1594 (36%) responded to the mailed survey. 1587 had valid PCS scores, and 1578 had valid MCS scores. Median time from diagnosis to survey completion was 68 months (IQR 62-73). Median age was 71 years. The mean PCS score was 39.66 (SD 12.38) and the mean MCS score was 53.32 (SD 9.94). For patients age 65-74 and 75+ respectively, PCS scores were 41.30 and 38.71, and MCS scores were 52.48 and 53.81 (vs population norms for women of 43.04 and 38.43 for PCS and 51.85 and 49.92 for MCS). Increasing age, unmarried status, Black race, lower education and income, higher comorbidity, and prior adjuvant chemotherapy were all significantly associated with lower PCS scores. Hispanic and Black race, lower education and income, higher comorbidity, and adjuvant endocrine therapy were significantly associated with lower MCS scores.
Conclusions
Among older breast cancer survivors, physical component scores among patients age 65-74 were lower and mental component scores among patients age 75+ were higher when compared to population norms for age and gender.
Clinical trial identification
Editorial acknowledgement
Legal entity responsible for the study
The authors.
Funding
CPRIT; Komen.
Disclosure
All authors have declared no conflicts of interest.